Results 11 to 20 of about 71,138 (196)
The role of dendritic spines in epileptogenesis. [PDF]
Front Cell Neurosci, 2023 Epilepsy is a chronic central nervous system (CNS) disease associated with high morbidity. To date, there is no known disease-modifying therapy for epilepsy. A leading hypothesis for a mechanism of epileptogenesis is the generation of aberrant neuronal networks.
Jean G, Carton J, Haq K, Musto AE.
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Superresolving Dendritic Spines [PDF]
Biophysical Journal, 2013 Spines are tiny protrusions that densely stud the dendrites of neurons in the brain. Individual spines are the primary recipients of synaptic inputs from single axons, which emanate from other neurons in the central nervous system. A dendritic tree on one neuron may have hundreds of thousands of spines, making connections to a corresponding number of ...
Loew, Leslie M., Hell, Stefan
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Signaling in dendritic spines and spine microdomains [PDF]
Current Opinion in Neurobiology, 2012 The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical ...
Yao, Chen, Bernardo L, Sabatini
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SpineTool is an open-source software for analysis of morphology of dendritic spines
Scientific Reports, 2023 Dendritic spines form most excitatory synaptic inputs in neurons and these spines are altered in many neurodevelopmental and neurodegenerative disorders.
Ekaterina Pchitskaya +4 more
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Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. [PDF]
, 2014 The earliest stages of Alzheimer's disease (AD) are characterized by deficits in memory and cognition indicating hippocampal pathology. While it is now recognized that synapse dysfunction precedes the hallmark pathological findings of AD, it is unclear ...
Antonios, Joseph K +6 more
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Changing the size of dendritic spines. [PDF]
Elife, 2023 Interactions between an enzyme kinase, an ion channel and cytoskeletal proteins maintain the structure of synapses involved in memory formation.
Saneyoshi T.
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Electrical properties of dendritic spines. [PDF]
Biophys J, 2023 Dendritic spines are small protrusions that mediate most of the excitatory synaptic transmission in the brain. Initially, the anatomical structure of spines has suggested that they serve as isolated biochemical and electrical compartments. Indeed, following ample experimental evidence, it is now widely accepted that a significant physiological role of ...
Zecevic D.
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St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2019 Neuronal cells are characterized by a close relationship between their functional state and morphology, especially such mobile structures as dendritic spines.
Pchitskaya Ekaterina +4 more
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Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework [PDF]
, 2005 The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we
Coombes, Stephen +2 more
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Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties
Cell Reports, 2019 Summary: Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization.
Angelica Foggetti +4 more
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