Results 51 to 60 of about 71,138 (196)
Frontiers in Cellular Neuroscience, 2018 Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD).
Iryna Hlushchenko +7 more
doaj +1 more source
Active elastohydrodynamics of vesicles in narrow, blind constrictions [PDF]
, 2017 Fluid-resistance limited transport of vesicles through narrow constrictions is a recurring theme in many biological and engineering applications. Inspired by the motor-driven movement of soft membrane-bound vesicles into closed neuronal dendritic spines,
Fai, Thomas G. +4 more
core +4 more sources
Pathology of Synapses and Dendritic Spines
Neural Plasticity, 2012 Peer ...
Shira Knafo +3 more
openaire +4 more sources
Dopaminergic signaling in dendritic spines [PDF]
Biochemical Pharmacology, 2008 Dopamine regulates movement, motivation, reward, and learning and is implicated in numerous neuropsychiatric and neurological disorders. The action of dopamine is mediated by a family of seven-transmembrane G protein-coupled receptors encoded by at least five dopamine receptor genes (D1, D2, D3, D4, and D5), some of which are major molecular targets ...
Wei-Dong, Yao +2 more
openaire +2 more sources
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1 [PDF]
, 2016 Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage.
Abel, Ted +14 more
core +6 more sources
Actin capping protein regulates postsynaptic spine development through CPI-motif interactions
Frontiers in Molecular Neuroscience, 2022 Dendritic spines are small actin-rich protrusions essential for the formation of functional circuits in the mammalian brain. During development, spines begin as dynamic filopodia-like protrusions that are then replaced by relatively stable spines ...
Kenneth R. Myers +6 more
doaj +1 more source
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. [PDF]
, 2010 Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use ...
Bolaños, Carlos A +26 more
core +3 more sources
Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines
Nature Communications, 2019 Activation of Ca2+/calmodulin-dependent kinase II (CaMKII) in dendritic spines is a key step of long-term potentiation (LTP) induction, yet the exact biochemical steps of CaMKIIα activation in dendritic spines remained elusive. In this study, the authors
Jui-Yun Chang +3 more
doaj +1 more source
PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]
, 2012 Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M +3 more
core +1 more source
Calcium Signaling in Dendritic Spines [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Calcium (Ca(2+)) is a ubiquitous signaling molecule that accumulates in the cytoplasm in response to diverse classes of stimuli and, in turn, regulates many aspects of cell function. In neurons, Ca(2+) influx in response to action potentials or synaptic stimulation triggers neurotransmitter release, modulates ion channels, induces synaptic plasticity ...
Michael J, Higley, Bernardo L, Sabatini
openaire +2 more sources