Synaptic remodeling in mouse motor cortex after spinal cord injury
Neural Regeneration Research, 2021 Spinal cord injury dramatically blocks information exchange between the central nervous system and the peripheral nervous system. The resulting fate of synapses in the motor cortex has not been well studied.
Ke-Xue Zhang +3 more
doaj +1 more source
Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons [PDF]
, 2019 Huntington\u27s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs).
Carrillo-Reid, Luis +13 more
core +1 more source
The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]
, 2017 One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A. +32 more
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The spine problem: finding a function for dendritic spines
Frontiers in Neuroanatomy, 2014 Why do neurons have dendritic spines? This question-the heart of what Yuste calls "the spine problem"-presupposes that why-questions of this sort have scientific answers: that empirical findings can favor or count against claims about why neurons have spines. Here we show how such questions can receive empirical answers.
Malanowski, Sarah, Craver, Carl F.
openaire +3 more sources
Dendritic spines are lost in clusters in Alzheimer’s disease
Scientific Reports, 2021 Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a deterioration of neuronal connectivity. The pathological accumulation of tau in neurons is one of the hallmarks of AD and has been connected to the loss of dendritic ...
Mite Mijalkov +5 more
doaj +1 more source
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L. +1 more
core +3 more sources
Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins.
PLoS ONE, 2016 Climbing fibres and parallel fibres compete for dendritic space on Purkinje cells in the cerebellum. Normally, climbing fibres populate the proximal dendrites, where they suppress the multiple small spines typical of parallel fibres, leading to their ...
Tristan G Heintz +2 more
doaj +1 more source
Sampling issues in quantitative analysis of dendritic spines morphology
BMC Bioinformatics, 2012 Background Quantitative analysis of changes in dendritic spine morphology has become an interesting issue in contemporary neuroscience. However, the diversity in dendritic spine population might seriously influence the result of measurements in which ...
Ruszczycki Błażej +6 more
doaj +1 more source
eLife, 2022 Dendritic spines are the central postsynaptic machinery that determines synaptic function. The F-actin within dendritic spines regulates their dynamic formation and elimination.
Soo Jeong Kim +9 more
doaj +1 more source
Subtype-specific plasticity of inhibitory circuits in motor cortex during motor learning. [PDF]
, 2015 Motor skill learning induces long-lasting reorganization of dendritic spines, principal sites of excitatory synapses, in the motor cortex. However, mechanisms that regulate these excitatory synaptic changes remain poorly understood.
Chen, Simon X +3 more
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