Results 81 to 90 of about 71,138 (196)
Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium. [PDF]
, 2019 Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes.
Bartol, Tom +3 more
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Protein synthesis at synaptic sites on dendrites [PDF]
, 2001 Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous ...
Schuman, Erin M., Steward, Oswald
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Structural plasticity of dendritic spines [PDF]
Current Opinion in Neurobiology, 2012 Dendritic spines are small mushroom-like protrusions arising from neurons where most excitatory synapses reside. Their peculiar shape suggests that spines can serve as an autonomous postsynaptic compartment that isolates chemical and electrical signaling.
Miquel, Bosch, Yasunori, Hayashi
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Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning [PDF]
, 2013 The present research investigated the resulting contextual fear memory and structural plasticity changes in the dorsal hippocampus (DH) following stress and fear conditioning. This combination enhanced fear retention and increased the number of total and
Calfa, Gaston Diego +2 more
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Actin cytoskeleton in dendritic spine
Folia Pharmacologica Japonica, 2007 樹状突起スパインは脳内の主要な興奮性シナプス後部であり，その形態および構成タンパク質の可塑的変化は学習記憶などの高次機能に重要である．スパイン内の構造体としては，シナプス後部肥厚（PSD）とアクチン細胞骨格があり，スパインの形態変化は主にアクチン細胞骨格により制御されている．スパイン内ではその頭部と頸部でアクチン線維の構造が異なることに加えて，頭部の中でもシナプス直下のPSD近傍と細胞質の中心領域でアクチン結合タンパク質の分布が異なる．したがって，スパインは3種類の性質の異なるアクチン細胞骨格によって構成されていると考えられる．アクチンを脱重合させると，多くのスパイン構成タンパク質の局在が不安定化し，スパイン形態もフィロポディア様に変化する．従って，アクチン細胞骨格がスパイン形態の形成 ...
Kenji, Hanamura, Tomoaki, Shirao
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Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
Nature Communications, 2020 In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.
Alberto Perez-Alvarez +5 more
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Geometric principles of second messenger dynamics in dendritic spines. [PDF]
, 2019 Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state.
Bartol, Thomas M +4 more
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Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation [PDF]
, 2013 Dendritic spines are major sites of excitatory synaptic transmission and changes in their numbers and morphology have been associated with neurodevelopmental and neurodegenerative disorders.
Galati, DF +3 more
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Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease
Neural Plasticity, 2012 Synapses are sites of cell-cell contacts that transmit electrical or chemical signals in the brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are located.
Wendou Yu, Bingwei Lu
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Journal of International Medical Research, 2023 Objectives To observe changes in actin and dendritic spines in the hippocampus after propofol anesthesia, and to evaluate the role of these changes in subsequent learning impairment in both young (3-month-old) and aged (20-month-old) male rats.
Xuena Zhang, Jie Li
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