Results 101 to 110 of about 71,138 (196)

CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex

Neural Plasticity, 2015
Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits. Although cAMP response element binding protein (CREB) has a key function in spines changes, its role in activity-dependent ...
Annabella Pignataro, Antonella Borreca, Martine Ammassari-Teule, Silvia Middei   +3 more
doaj   +1 more source

Analysis of quantification methods used for cell viability, cell morphology, and synaptic formation in modeling HIV associated dementia in primary neuronal cultures. [PDF]

, 2009
Change is inevitable, changes in neuronal function occur in physiologic and pathologic processes. The ability to reliably analyze and quantify those changes in neuronal morphology and function has been an important part of technical developments in ...
Saunders, John James
core  

Assessing protein distribution and dendritic spine morphology relationships using structured illumination microscopy in cultured neurons

STAR Protocols
Summary: Dendritic spines are protrusions on dendrites forming the postsynaptic aspect of excitatory connections within the brain. Spine morphology is associated with synaptic functional strength and the spatial regulation of protein nanodomains within ...
Kathryn J. Bjornson, Michael E. Cahill
doaj   +1 more source

Remodeling dendritic spines for treatment of traumatic brain injury

Neural Regeneration Research, 2019
Traumatic brain injury is an important global public health problem. Traumatic brain injury not only causes neural cell death, but also induces dendritic spine degeneration. Spared neurons from cell death in the injured brain may exhibit dendrite damage,
Ye Xiong, Asim Mahmood, Michael Chopp
doaj   +1 more source

Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function. [PDF]

, 2019
Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the atypical protein
Cheng, Hongqiang, Ghosh, Sourav, Hejran, Helen, Klezovitch, Olga, Lee, Su-Yee, Mao, Ye, Mu, Yongxin, Qin, Huaping, Scott, John, Thakar, Sonal, Vasioukhin, Valeri, Yu, Ting, Zou, Yimin   +12 more
core   +1 more source

The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders

Neural Plasticity, 2016
Dendritic spines are the location of excitatory synapses in the mammalian nervous system and are neuron-specific subcellular structures essential for neural circuitry and function. Dendritic spine morphology is determined by the F-actin cytoskeleton.
Hsiao-Tang Hu, Pu-Yun Shih, Yu-Tzu Shih, Yi-Ping Hsueh   +3 more
doaj   +1 more source

Regulation of Dendrite and Dendritic Spine Formation by TCF20

Journal of Neurochemistry
ABSTRACT Mutations in the Transcription Factor 20 (TCF20) have been identified in patients with autism spectrum disorders (ASDs), intellectual disabilities (IDs), and other neurological issues. Recently, a new syndrome called TCF20‐associated neurodevelopmental disorders (TAND) has been described, with specific ...
Vinci E., Beretta S., Colombo V., Zippo A., Catanese A., Wiegreffe C., Britsch S., Boeckers T., Verpelli C., Sala C.   +9 more
openaire   +3 more sources

A Multi-Network Approach Identifies Proteins Related to Dendritic Spines in Alzheimer's Disease. [PDF]

eNeuro
Hobby EL, Weber AJ, Liu E, Hurst C, Greathouse KM, Gaiteri C, Seyfried NT, Herskowitz JH.   +7 more
europepmc   +1 more source

Kinetochore proteins control microtubule dynamics in postmitotic neurons to regulate the formation of dendritic spines. [PDF]

Proc Natl Acad Sci U S A
Zhao G, Sharma A, Tang J, Aleman M, Liang X, Miner L, Qi J, Xiang W, Tian F, Goldberg Y, He Z, Shen K, Peris L, L Schwarz T.   +13 more
europepmc   +1 more source

Distinct spatial distribution of potentiated dendritic spines in encoding- and recall-activated hippocampal neurons. [PDF]

Front Mol Neurosci
Gobbo F, Jacob A, Pinto B, Mainardi M, Cancedda L, Cattaneo A.   +5 more
europepmc   +1 more source