Results 91 to 100 of about 71,138 (196)
Abnormal microglia and enhanced inflammation-related gene transcription in mice with conditional deletion of Ctcf in Camk2a-Cre-expressing neurons [PDF]
, 2017 CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates gene expression by modifying 3D chromatin structure. Human mutations inCTCFcause intellectual disability and autistic features.
Barve, Ruteja A +9 more
core +2 more sources
Prevention of Neurite Spine Loss Induced by Dopamine D2 Receptor Overactivation in Striatal Neurons
Frontiers in Neuroscience, 2020 Psychosis has been considered a disorder of impaired neuronal connectivity. Evidence for excessive formation of dopamine D2 receptor (D2R) – disrupted in schizophrenia 1 (DISC1) complexes has led to a new perspective on molecular mechanisms involved in ...
Peng Zheng +4 more
doaj +1 more source
Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments [PDF]
, 2003 Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory synaptic transmission and dendritic spine morphology. We report that spinophilin is phosphorylated in vitro by protein kinase A (PKA).
Allen, Patrick B. +5 more
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Continuous volumetric imaging via an optical phase-locked ultrasound lens
, 2016 In vivo imaging at high spatiotemporal resolution is key to the understanding of complex biological systems. We integrated an optical phase-locked ultrasound lens into a two-photon fluorescence microscope and achieved microsecond-scale axial scanning ...
Cui, M. +7 more
core +1 more source
Nature Communications, 2016 Transport of cargo into dendritic spines is required for synaptic plasticity. McVicker et al.describe a method of activity-dependent transport of a kinesin KIF1A and its cargo synaptotagmin-IV along microtubules that are transiently polymerized into ...
Derrick P. McVicker +7 more
doaj +1 more source
Matrix metalloproteinase-9 involvement in the structural plasticity of dendritic spines.
Frontiers in Neuroanatomy, 2014 Dendritic spines are the locus for excitatory synaptic transmission in the brain and thus play a major role in neuronal plasticity. The ability to alter synaptic connections includes volumetric changes in dendritic spines that are driven by scaffolds ...
Michal eStawarski +2 more
doaj +1 more source
A spike-timing-dependent plasticity rule for dendritic spines
Nature Communications, 2020 The structural organization of excitatory inputs supporting spike-timing-dependent plasticity (STDP) in dendritic spines remains unknown. Using a spine STDP protocol, the authors uncover the STDP rules for single, clustered and distributed dendritic ...
Sabrina Tazerart +3 more
doaj +1 more source
Dendritic Spines and Distributed Circuits [PDF]
Neuron, 2011 Dendritic spines receive most excitatory connections in pyramidal cells and many other principal neurons. But why do neurons use spines, when they could accommodate excitatory contacts directly on their dendritic shafts? One suggestion is that spines serve to connect with passing axons, thus increasing the connectivity of the dendrites.
openaire +2 more sources
Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain. [PDF]
, 2020 Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads to normal tissue damage that can induce unintended neurocognitive complications that are progressive and debilitating. Ionizing radiation exposure has also been
Acharya, Munjal M +13 more
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