Results 21 to 30 of about 58,744 (263)
Pathology of Synapses and Dendritic Spines
Neural Plasticity, 2012 Peer ...
Shira Knafo +3 more
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The spine problem: finding a function for dendritic spines
Frontiers in Neuroanatomy, 2014 Why do neurons have dendritic spines? This question-the heart of what Yuste calls "the spine problem"-presupposes that why-questions of this sort have scientific answers: that empirical findings can favor or count against claims about why neurons have spines. Here we show how such questions can receive empirical answers.
Malanowski, Sarah, Craver, Carl F.
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ApoE receptor 2 regulates synapse and dendritic spine formation.
PLoS ONE, 2011 BackgroundApolipoprotein E receptor 2 (ApoEr2) is a postsynaptic protein involved in long-term potentiation (LTP), learning, and memory through unknown mechanisms.
Sonya B Dumanis +10 more
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Calcium Dynamics in Dendritic Spines and Spine Motility [PDF]
Biophysical Journal, 2004 A dendritic spine is an intracellular compartment in synapses of central neurons. The role of the fast twitching of spines, brought about by a transient rise of internal calcium concentration above that of the parent dendrite, has been hitherto unclear.
Holcman, D., Schuss, Z., Korkotian, E.
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Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease
Neural Plasticity, 2012 Synapses are sites of cell-cell contacts that transmit electrical or chemical signals in the brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are located.
Wendou Yu, Bingwei Lu
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Scientific Reports, 2023 Cognitive functions decline during aging. This decline could be caused by changes in dendritic spine stability and altered spine dynamics. Previously, we have shown that a low dose chronic THC treatment improves learning abilities in old whereas impairs ...
Joanna Agnieszka Komorowska-Müller +5 more
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Ecotoxicology and Environmental Safety, 2023 Lead (Pb), cadmium (Cd), and mercury (Hg) are environmentally toxic heavy metals that can be simultaneously detected at low levels in the blood of the general population. Although our previous studies have demonstrated neurodevelopmental toxicity upon co-
Fankun Zhou +17 more
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Calcium Signaling in Dendritic Spines [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Calcium (Ca(2+)) is a ubiquitous signaling molecule that accumulates in the cytoplasm in response to diverse classes of stimuli and, in turn, regulates many aspects of cell function. In neurons, Ca(2+) influx in response to action potentials or synaptic stimulation triggers neurotransmitter release, modulates ion channels, induces synaptic plasticity ...
Michael J, Higley, Bernardo L, Sabatini
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Neural Plasticity, 2012 Alterations in dendritic spines have been documented in numerous neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, an X chromosome-linked disorder associated with mutations in MECP2, is the leading cause of ...
Christopher A. Chapleau +5 more
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Disease Models & Mechanisms, 2022 Dendritic spines are the principal site of excitatory synapse formation in the human brain. Several neurodevelopmental disorders cause spines to develop abnormally, resulting in altered spine number and morphology.
Elisabeth C. DeMarco +2 more
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