Results 11 to 20 of about 58,744 (263)
The role of dendritic spines in epileptogenesis
Frontiers in Cellular Neuroscience, 2023 Epilepsy is a chronic central nervous system (CNS) disease associated with high morbidity. To date, there is no known disease-modifying therapy for epilepsy.
Gary Jean +4 more
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Superresolving Dendritic Spines [PDF]
Biophysical Journal, 2013 Spines are tiny protrusions that densely stud the dendrites of neurons in the brain. Individual spines are the primary recipients of synaptic inputs from single axons, which emanate from other neurons in the central nervous system. A dendritic tree on one neuron may have hundreds of thousands of spines, making connections to a corresponding number of ...
Loew, Leslie M., Hell, Stefan
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Signaling in dendritic spines and spine microdomains [PDF]
Current Opinion in Neurobiology, 2012 The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical ...
Yao, Chen, Bernardo L, Sabatini
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Cell Reports, 2014 Sensory experience regulates the development of various brain structures, including the cortex, hippocampus, and olfactory bulb (OB). Little is known about how sensory experience regulates the dendritic spine development of OB interneurons, such as ...
Sei-ichi Yoshihara +11 more
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Reaction–Diffusion Model-Based Research on Formation Mechanism of Neuron Dendritic Spine Patterns
Frontiers in Neurorobotics, 2021 The pattern abnormalities of dendritic spine, tiny protrusions on neuron dendrites, have been found related to multiple nervous system diseases, such as Parkinson's disease and schizophrenia.
Yiqing Jia +6 more
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Frontiers in Cellular Neuroscience, 2018 Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD).
Iryna Hlushchenko +7 more
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The discovery of dendritic spines by Cajal [PDF]
Frontiers in Neuroanatomy, 2015 Dendritic spines were considered an artifact of the Golgi method until a brash Spanish histologist, Santiago Ramón y Cajal, bet his scientific career arguing that they were indeed real, correctly deducing their key role in mediating synaptic connectivity.
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Regulation of Dendrite and Dendritic Spine Formation by TCF20. [PDF]
J NeurochemABSTRACT Mutations in the Transcription Factor 20 (TCF20) have been identified in patients with autism spectrum disorders (ASDs), intellectual disabilities (IDs), and other neurological issues. Recently, a new syndrome called TCF20‐associated neurodevelopmental disorders (TAND) has been described, with specific ...
Vinci E +9 more
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Neurodevelopmental disorder-associated ZBTB20 gene variants affect dendritic and synaptic structure.
PLoS ONE, 2018 Dendritic spine morphology and dendritic arborization are key determinants of neuronal connectivity and play critical roles in learning, memory and behavior function.
Kelly A Jones +8 more
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Neurobiology of Disease, 2009 Rett syndrome (RTT) is an X chromosome-linked neurodevelopmental disorder associated with the characteristic neuropathology of dendritic spines common in diseases presenting with mental retardation (MR).
Christopher A. Chapleau +8 more
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