The role of dendritic spines in epileptogenesis
Frontiers in Cellular Neuroscience, 2023 Epilepsy is a chronic central nervous system (CNS) disease associated with high morbidity. To date, there is no known disease-modifying therapy for epilepsy.
Gary Jean +4 more
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Superresolving Dendritic Spines [PDF]
Biophysical Journal, 2013 Spines are tiny protrusions that densely stud the dendrites of neurons in the brain. Individual spines are the primary recipients of synaptic inputs from single axons, which emanate from other neurons in the central nervous system. A dendritic tree on one neuron may have hundreds of thousands of spines, making connections to a corresponding number of ...
Loew, Leslie M., Hell, Stefan
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Signaling in dendritic spines and spine microdomains [PDF]
Current Opinion in Neurobiology, 2012 The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical ...
Yao, Chen, Bernardo L, Sabatini
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The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus [PDF]
, 2016 Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression.
Aguayo, F. +12 more
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Frontiers in Cellular Neuroscience, 2017 Psychostimulant drugs of abuse increase dendritic spine density in reward centers of the brain. However, little is known about their effects in the hippocampus, where activity-dependent changes in the density of dendritic spine are associated with ...
Soledad Ferreras +13 more
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Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus. [PDF]
PLoS Computational Biology, 2014 Temporal lobe epilepsy strongly affects hippocampal dentate gyrus granule cells morphology. These cells exhibit seizure-induced anatomical alterations including mossy fiber sprouting, changes in the apical and basal dendritic tree and suffer substantial ...
Julian Tejada +2 more
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Cell Reports, 2014 Sensory experience regulates the development of various brain structures, including the cortex, hippocampus, and olfactory bulb (OB). Little is known about how sensory experience regulates the dendritic spine development of OB interneurons, such as ...
Sei-ichi Yoshihara +11 more
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Reaction–Diffusion Model-Based Research on Formation Mechanism of Neuron Dendritic Spine Patterns
Frontiers in Neurorobotics, 2021 The pattern abnormalities of dendritic spine, tiny protrusions on neuron dendrites, have been found related to multiple nervous system diseases, such as Parkinson's disease and schizophrenia.
Yiqing Jia +6 more
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Early intervention combined with targeted treatment promotes cognitive and behavioral improvements in young children with fragile x syndrome. [PDF]
, 2012 Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability due to an expansion in the full mutation range (>200 CGG repeats) of the promoter region of the FMR1 gene leading to gene silencing.
Borodyanskara, Mariya +3 more
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Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework [PDF]
, 2005 The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we
Coombes, Stephen +2 more
core +2 more sources