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Dendritic Spine Plasticity and Cognition [PDF]
Neural Plasticity, 2012 The scientific studies of dendritic spines have experienced an overwhelming growth in the last three decades. Since the primary concept that dendritic spines are sites of excitatory synaptic contact, the most recent studies have led to theoretical proposals that relate spines' morphophysiology with the information processing that underlies cognition ...
González Burgos, Ignacio +2 more
openaire +4 more sources
Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease
Neural Plasticity, 2012 Synapses are sites of cell-cell contacts that transmit electrical or chemical signals in the brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are located.
Wendou Yu, Bingwei Lu
doaj +1 more source
Scientific Reports, 2023 Cognitive functions decline during aging. This decline could be caused by changes in dendritic spine stability and altered spine dynamics. Previously, we have shown that a low dose chronic THC treatment improves learning abilities in old whereas impairs ...
Joanna Agnieszka Komorowska-Müller +5 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2023 Lead (Pb), cadmium (Cd), and mercury (Hg) are environmentally toxic heavy metals that can be simultaneously detected at low levels in the blood of the general population. Although our previous studies have demonstrated neurodevelopmental toxicity upon co-
Fankun Zhou +17 more
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Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]
, 2016 During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo +5 more
core +2 more sources
Microtubules in Dendritic Spine Development [PDF]
The Journal of Neuroscience, 2008 It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that microtubules (MTs) are present in spines and that shRNA knockdown of the MT plus-end-binding protein EB3 significantly reduces spine formation.
Jiaping, Gu +2 more
openaire +2 more sources
Neural Plasticity, 2012 Alterations in dendritic spines have been documented in numerous neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, an X chromosome-linked disorder associated with mutations in MECP2, is the leading cause of ...
Christopher A. Chapleau +5 more
doaj +1 more source
Disease Models & Mechanisms, 2022 Dendritic spines are the principal site of excitatory synapse formation in the human brain. Several neurodevelopmental disorders cause spines to develop abnormally, resulting in altered spine number and morphology.
Elisabeth C. DeMarco +2 more
doaj +1 more source
Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability [PDF]
, 2015 Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist?
Smolen, Paul
core +4 more sources
NeuroImageMemory is closely associated with neuronal activity and dendritic spine formation. Low-intensity transcranial ultrasound stimulation (TUS) improves the memory of individuals with vascular dementia (VD).
Jiamin Pei +5 more
doaj +1 more source