Results 51 to 60 of about 95,281 (299)

Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain. [PDF]

, 2020
Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads to normal tissue damage that can induce unintended neurocognitive complications that are progressive and debilitating. Ionizing radiation exposure has also been
Acharya, Munjal M, Angulo, Maria C, Baulch, Janet E, Chmielewski, Nicole N, Giedzinski, Erich, Liang, Yaxuan, Limoli, Charles L, Lu, Celine, Lui, Tiffany, Martirosian, Vahan, Park, Audrey L, Ru, Ning, Smith, Sarah M, Tang, Sharon   +13 more
core  

Active elastohydrodynamics of vesicles in narrow, blind constrictions [PDF]

, 2017
Fluid-resistance limited transport of vesicles through narrow constrictions is a recurring theme in many biological and engineering applications. Inspired by the motor-driven movement of soft membrane-bound vesicles into closed neuronal dendritic spines,
Fai, Thomas G., Harting, Jens, Kusters, Remy, Mahadevan, L., Rycroft, Chris H.   +4 more
core   +4 more sources

Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat

Scientific Reports, 2020
Stress alters the structure and function of brain reward circuitry and is an important risk factor for developing depression. In the nucleus accumbens (NAc), structural and physiological plasticity of medium spiny neurons (MSNs) have been linked to ...
Megan E. Fox, Antonio Figueiredo, Miriam S. Menken, Mary Kay Lobo   +3 more
doaj   +1 more source

Image informatics strategies for deciphering neuronal network connectivity [PDF]

, 2016
Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions.
A Dani, A Rodriguez, A Rodriguez, A Rodriguez, B Deleglise, B Zhang, BA Wilt, C Sala, CG Dotti, D Cai, D Gerlich, D Popova, D Prodanov, D Smetters, DA Dombeck, DA Dombeck, DW Godwin, E Cohen, E Fluhler, E Meijering, E Meijering, E Meijering, EW Dent, F Cornelissen, F Janoos, G Pani, GG Gurkoff, GP Feng, GS Belinsky, H Bading, H Chen, H Peng, H Peng, HH Piao, IR Wickersham, IY Koh, J Cheng, J Fan, J Fan, J Lammerding, J Liu, J Livet, JA Harrill, JI Luebke, JL Chen, JM Nussbaum, K Chung, K Deisseroth, K Imamura, K Takahashi, KA Al-Kofahi, KD Micheva, KE Binley, KM Brown, KO Lai, KR Kay, L Bretzner, L Feng, L Grosenick, L Jin, L Jin, LD Costa, M Meijer, M Naujock, M Papa, M Pickering, M Pool, M Wittmann, ML Narro, MS Siegel, N Heck, O Sirenko, P Chothani, P Maiti, P Penzes, P Roqué, P Sarder, P Shi, P Verstraelen, Q Li, Q Li, R Nair, R Parekh, RA McKinney, RM Paredes, S Cho, S Schmitt, SK Schmitz, SL Wearne, SY Ho, SY Kim, T Nemoto, T Zhao, TL Fletcher, VA Alvarez, W Bai, WH Vos De, Y Al-Kofahi, Y Zhang, YC Lin   +99 more
core   +2 more sources

Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]

, 2015
Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Heller, JP, Rusakov, DA
core   +1 more source

Calcium Signaling in Dendritic Spines [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Calcium (Ca(2+)) is a ubiquitous signaling molecule that accumulates in the cytoplasm in response to diverse classes of stimuli and, in turn, regulates many aspects of cell function. In neurons, Ca(2+) influx in response to action potentials or synaptic stimulation triggers neurotransmitter release, modulates ion channels, induces synaptic plasticity ...
Michael J, Higley, Bernardo L, Sabatini
openaire   +2 more sources

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Geometric principles of second messenger dynamics in dendritic spines. [PDF]

, 2019
Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state.
Bartol, Thomas M, Cugno, Andrea, Iyengar, Ravi, Rangamani, Padmini, Sejnowski, Terrence J   +4 more
core   +1 more source

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. [PDF]

, 2010
Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use ...
Bolaños, Carlos A, Covington, Herbert E, Dietz, David M, Dumitriu, Dani, Eisch, Amelia J, Fan, Gouping, Feng, Jian, Hollis, Fiona, Hurd, Yasmin L, Iñiguez, Sergio D, Kabbaj, Mohamed, Koo, Ja Wook, LaPlant, Quincey, Maze, Ian, Morrison, John H, Mouzon, Ezekiell, Nestler, Eric J, Neve, Rachael L, Noonan, Michele A, Oosting, Ronald S, Ren, Yanhua, Renthal, William, Vialou, Vincent, Wang, Hui, Warren, Brandon L, Watts, Emily L, Xiao, Guanghua   +26 more
core   +3 more sources

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source