Results 61 to 70 of about 95,281 (299)
Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism. [PDF]
PLoS ONE, 2014 General anesthetics produce a reversible coma-like state through modulation of excitatory and inhibitory synaptic transmission. Recent evidence suggests that anesthetic exposure can also lead to sustained cognitive dysfunction.
Jimcy Platholi +3 more
doaj +1 more source
PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]
, 2012 Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M +3 more
core +1 more source
Regulation of Dendrite and Dendritic Spine Formation by TCF20. [PDF]
J NeurochemABSTRACT Mutations in the Transcription Factor 20 (TCF20) have been identified in patients with autism spectrum disorders (ASDs), intellectual disabilities (IDs), and other neurological issues. Recently, a new syndrome called TCF20‐associated neurodevelopmental disorders (TAND) has been described, with specific ...
Vinci E +9 more
europepmc +4 more sources
The spine problem: finding a function for dendritic spines
Frontiers in Neuroanatomy, 2014 Why do neurons have dendritic spines? This question-the heart of what Yuste calls "the spine problem"-presupposes that why-questions of this sort have scientific answers: that empirical findings can favor or count against claims about why neurons have spines. Here we show how such questions can receive empirical answers.
Malanowski, Sarah, Craver, Carl F.
openaire +3 more sources
Advanced Materials, EarlyView.This review traces the evolution of lithium‐ion battery separators from passive barriers to multifunctional components central to cell safety and performance. Polymer‐ceramic hybrids, nanofiber architectures, and bio‐derived membranes deliver ionic conductivities above 3 mS cm−1, thermal stability beyond 200 °C, and effective suppression of lithium ...
Karthik Vishweswariah +5 more
wiley +1 more source
Neural Plasticity, 2016 Dendritic spines are the location of excitatory synapses in the mammalian nervous system and are neuron-specific subcellular structures essential for neural circuitry and function. Dendritic spine morphology is determined by the F-actin cytoskeleton.
Hsiao-Tang Hu +3 more
doaj +1 more source
The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice. [PDF]
, 2018 Zinc (Zn2+) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn2+ levels triggers neurotoxic processes and affects neuronal functioning.
Bomba, Manuela +13 more
core +3 more sources
Advanced Materials Interfaces, EarlyView.Interfacial charge transfer and low‐resistance interphase formation between PEO‐based polymer and Li10GeP2S12 solid electrolytes are investigated using multi‐electrode impedance spectroscopy and advanced analytical techniques such as XPS and ToF‐SIMS.
Ujjawal Sigar +6 more
wiley +1 more source
PTEN: A master regulator of neuronal structure, function, and plasticity. [PDF]
, 2014 PTEN (phosphatase and tensin homolog on chromosome ten) is a dual protein/lipid phosphatase that dephosphorylates PIP3, thereby inhibiting the AKT/mTOR pathway. This inhibition ultimately decreases protein translation, cell proliferation and cell growth.
Garcia-Junco-Clemente, Pablo +1 more
core +1 more source
Organization of TNIK in dendritic spines [PDF]
Journal of Comparative Neurology, 2015 ABSTRACTTumor necrosis factor receptor‐associated factor 2 (TRAF2)‐ and noncatalytic region of tyrosine kinase (NCK)‐interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high‐resolution light and electron ...
Alain C, Burette +11 more
openaire +2 more sources