Results 31 to 40 of about 924,020 (209)

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle

Cell Communication and Signaling, 2018
Background Transforming growth factor beta 1 (TGF-β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration and muscle function in skeletal muscle diseases. Skeletal muscle atrophy, characterized by
Xiaofan Yang, Pingping Xue, Xin Liu, Xiang Xu, Zhenbing Chen   +4 more
doaj   +1 more source

Intramuscular injection of skeletal muscle derived extracellular matrix mitigates denervation atrophy after sciatic nerve transection

Journal of Tissue Engineering, 2021
Peripheral nerve injury and the associated muscle atrophy has an estimated annual healthcare burden of $150 billion dollars in the United States. When considering the total annual health-related spending of $3.5 trillion, these pathologies alone occupy ...
Benjamin K Schilling, Jocelyn S Baker, Chiaki Komatsu, Kacey G Marra   +3 more
doaj   +1 more source

Expert consensus on neuro‐musculoskeletal functional reconstruction for post‐stroke spastic hemiplegia

Ibrain, EarlyView.
This expert consensus proposes a patient‐centered pathway for functional reconstruction after post‐stroke spastic hemiplegia: “patient goal–pathophysiologic component–treatment target–functional reassessment.” Treatment selection and sequencing across motor retraining, brain–computer interfaces, peripheral nerve surgery, and tendon/soft‐tissue ...
Peng Wen, Yihe Wang, Zhongzheng He, Zhizhong Zhu, Chunbing Chen, Kaifeng Wu, Xiaohong Fu, Guoguang Zhao, Liulin Xiong, “Zunyi Brain‐Computer Interface Medical Center” Working Group, Denggui Cheng, Zhaojian Deng, Min Gong, Chong Han, Qijun Jiang, Hang Li, Jianping Li, Shun Li, Yu Li, Minjie Luo, Chiyuan Ma, Yongzhi Shan, Jun Wang, Nana Wang, Qinglan Wang, Ziheng Wang, Zhongying Wei, Guojun Wu, Bo Xiong, Jianguo Xu, Minpeng Xu, Kaihua Yang, Xi Yang, Fan Zhang, Hongtian Zhang, Jing Zhang, Shaofu Zhang, Hongxin Zhao, Min Zhao, Mingjiang Zhu   +39 more
wiley   +1 more source

Inflammation and apoptosis accelerate progression to irreversible atrophy in denervated intrinsic muscles of the hand compared with biceps: proteomic analysis of a rat model of obstetric brachial plexus palsy

Neural Regeneration Research, 2020
In treating patients with obstetric brachial plexus palsy, we noticed that denervated intrinsic muscles of the hand become irreversibly atrophic at a faster than denervated biceps.
Xiao-Heng Yu, Ji-Xin Wu, Liang Chen, Yu-Dong Gu   +3 more
doaj   +1 more source

Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy

Redox Biology, 2022
Loss of innervation is a key driver of age associated muscle atrophy and weakness (sarcopenia). Our laboratory has previously shown that denervation induced atrophy is associated with the generation of mitochondrial hydroperoxides and lipid mediators ...
Jacob L. Brown, Fredrick F. Peelor, III, Constantin Georgescu, Jonathan D. Wren, Michael Kinter, Victoria J. Tyrrell, Valerie B. O'Donnell, Benjamin F. Miller, Holly Van Remmen   +8 more
doaj   +1 more source

Novel Injectable Supports Long‐Term Recurrent Laryngeal Nerve and Partial Peripheral Nerve Repair

The Laryngoscope, EarlyView.
Following recurrent laryngeal nerve transection in C57BL/6 mice, intramuscular Agrin, neuregulin‐1, and acetylcholine treatment of the thyroarytenoid muscle supported functional reinnervation and preservation of neuromuscular structure at 84 days.
Aditya Bhatt, William Boswell, Elena Kennedy, Sunjay Anekal, Emma Mazurek, Ananya Tadikonda, Christopher Rafalko, Jasmine Strelow, Isaac Shipchandler, Patrick R. Finnegan, Stacey Halum   +10 more
wiley   +1 more source

Eletroestimulação seletiva mantem estrutura e função do tibial anterior desnervado de ratos Structure and function of denervated tibialis anteriores are maintained by electrical stimulation in rats

Acta Ortopédica Brasileira, 2010
OBJETIVO: A eletroestimulação para tratamento de músculos desnervados deve ser aplicada através do tratamento seletivo. Este estudo avaliou o efeito da eletroestimulação seletiva do músculo desnervado sobre sua estrutura e função.
Juliana de Tillio Polônio, Nilton Mazzer, Cláudio Henrique Barbieri, Ana Claudia Mattiello-Sverzut   +3 more
doaj   +1 more source

Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Ageing and cachexia cause a loss of muscle mass over time, indicating that protein breakdown exceeds protein synthesis. Deuterium oxide (D2O) is used for studies of protein turnover because of the advantages of long‐term labelling, but these ...
Kamil A. Kobak, Marcus M. Lawrence, Gavin Pharaoh, Agnieszka K. Borowik, Frederick F. Peelor III, Patrick D. Shipman, Timothy M. Griffin, Holly Van Remmen, Benjamin F. Miller   +8 more
doaj   +1 more source

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications

Muscle &Nerve, EarlyView.
ABSTRACT Peripheral nerve injuries (PNIs) are a common cause of long‐term motor and sensory disability despite advances in microsurgical repair. Functional recovery following PNI depends not only on axonal regeneration, but also on preservation of distal nerve pathways, maintenance of neuromuscular junction integrity, prevention of irreversible muscle ...
Sarah M. Smith, Kirsten M. Schlosser, Ranee Munaim, Stephanie H. Vu, JulieAnn H. Uh, Yusha K. Liu   +5 more
wiley   +1 more source