Results 181 to 190 of about 68,195 (311)

Parkinson's disease under dopamine replacement therapy as a human framework for studying addiction‐relevant mechanisms

Psychiatry and Clinical Neurosciences, EarlyView.
Addiction is a chronic relapsing condition characterized by compulsive reward seeking and impaired behavioral control, associated with major individual and societal burden. Mechanistic investigation in humans remains constrained by ethical limitations, uncontrolled exposure histories, and ecological confounds.
Vanessa Fleury, Elvira Pirondini, Damien Benis, Tiffany Corbet, Gabriel Thorens, Christian Lüscher, Paul Krack   +6 more
wiley   +1 more source

Renal and Functional Vulnerability in Hansen Disease: A Framework for Chronic Infectious Disability in Endemic Settings

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objectives Hansen disease is a neglected infectious disease associated with reactional inflammation, neuropathy and long‐term disability. Renal involvement and sarcopenia have been described separately, but their clinical coexistence has received limited attention. This review examines evidence for a hypothesised renal–functional vulnerability
Kleberson de Oliveira, Lucas Maciel de Almeida Corrêa, Isabela Malerba Pinheiro, Alexandre de Assis Barbosa, Maria Eduarda Castro Gonçalves, Lara Lucena Fernandes Filgueiras, Lara Reis Gomes de Mello Queiroz   +6 more
wiley   +1 more source

The Pericapsular Nerve Group (PENG) block in physical and rehabilitation medicine: an opinion paper. [PDF]

J Rehabil Med
Butet S, Genet F, Guignans C, Geffrier A, Bonan I.   +4 more
europepmc   +1 more source

Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?

Experimental Physiology, EarlyView.
Abstract Understanding the turnover of proteins in tissues gives information as to how external stimuli result in phenotypic change. Nowhere is such phenotypic change more conspicuous than skeletal muscle, which can be effectively remodelled by increased loading, ageing and unloading (disuse), all of which are subject to modification by nutrition and ...
Changhyun Lim, James McKendry, Matthew Lees, Philip J. Atherton, Nicholas A. Burd, Andrew M. Holwerda, Luc J. C. van Loon, Chris McGlory, Cameron J. Mitchell, Kenneth Smith, Daniel J. Wilkinson, Tanner Stokes, Stuart M. Phillips   +12 more
wiley   +1 more source

A long-acting injectable nanoparticle-hydrogel depot enables sustained IGF-1 delivery to reverse chronic denervation. [PDF]

Cell Biomater
Zhang Y, Harris TGW, Erb CJ, Qiu C, Sarhane KA, Hanwright P, Slavin BR, Yao ZC, Kong J, Lee EB, von Guionneau N, Khong J, Suresh R, Matar DY, Tinana AJ, Lee M, Iglesias M, Glass C, Hricz N, Pinni S, Generoso M, Suresh V, Cetinkaya-Fisgin A, Hutchinson EK, Izzi J, Segna K, Reddy S, Höke A, Mao HQ, Tuffaha SH.   +29 more
europepmc   +1 more source

Redox‐regulated signalling of adaptations to contractile activity in skeletal muscle: Implications for age‐related muscle weakness

Experimental Physiology, EarlyView.
Abstract Skeletal muscle adaptation to contractile activity is modulated by redox signalling, primarily through reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Early research framed ROS as deleterious byproducts of exercise, but subsequent studies have established their roles as signalling molecules involved in mitochondrial biogenesis,
Malcolm J. Jackson
wiley   +1 more source

Cadaveric study on feasibility of elbow joint denervation through a single posterior incision. [PDF]

JSES Rev Rep Tech
Kwee E, Zuidam JM, Debeij J, van Riet R, Colaris J, Eygendaal D, Hundepool CA.   +6 more
europepmc   +1 more source

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

Experimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova, Evgenii Lysenko, Fabio Sarto, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +6 more
wiley   +1 more source

Recent update on renal denervation: where do we stand now? [PDF]

Clin Hypertens
Shin J, Yoon YW.
europepmc   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source