Results 201 to 210 of about 68,195 (311)

Molecular signatures of selective motor neuron vulnerability in old age

Experimental Physiology, EarlyView.
Abstract Motor neuron (MN) death and impairment of fast‐fatigable motor units is widely recognized in elderly humans and rats. However, the molecular signatures identifying vulnerable MNs remains underexplored. In murine models of amyotrophic lateral sclerosis, matrix metalloproteinase 9 (MMP‐9) and chondrolectin (Chodl) decline with disease ...
Sang Won Cheung, Matthew J. Fogarty
wiley   +1 more source

Sciatic denervation differentially remodels skeletal muscle and deep fascia in the lower limb of male mice. [PDF]

Physiol Rep
Otsuka S, Tamaki Y, Umemoto K, Hatayama N, Naito M.   +4 more
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

S100A8/S100A9 released by CD11b⁺Ly6G⁺ neutrophils activate MerTK^hiLy6c^lo reparative macrophages to delay denervated muscle atrophy. [PDF]

Exp Mol Med
Xiang Y, Zhu L, Qiu Z, You Z, Dai J, Xu L, Jiang J, Xu J.   +7 more
europepmc   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Peripheral Nerve Injury and Denervation-Induced Sarcopenia with a Focus on Pharmacological Dual-Target Strategies. [PDF]

Biomol Ther (Seoul)
Yun C, Won JH, Lee SY, Kim TH, Kim GH, Lee JI.   +5 more
europepmc   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Nonspecific Effects in Atrial Fibrillation Ablation: Insights From SHAM-PVI and Other Sham-Controlled Trials, Methodology Corner. [PDF]

JACC Adv
Williams JL, Bizanti A, Khanna A, Nass O, Hyun S, Fernandez J.   +5 more
europepmc   +1 more source

Development of Renal Denervation Catheter Based on Piezoelectric Ultrasonic Transducer. [PDF]

Micromachines (Basel)
Li Q, Zhou T, Qin D, Wu Y, Li X, Li S, Chen X, Wu Z.   +7 more
europepmc   +1 more source