Results 1 to 10 of about 17,567 (255)

Combining free muscle flap lower limb reconstruction with targeted muscle reinnervation: A novel strategy to prevent neuropathic pain and promote sensory restoration [PDF]

JPRAS Open
Background: Severe lower extremity trauma with extensive tissue loss is often reconstructed using free muscle flaps. However, it involves vascular anastomosis but no nerve coaptation at the recipient site.
Camille Blaaker, Mirte Langeveld, Antonius J.M. Luijsterburg, J. Michiel Zuidam, Caroline A. Hundepool   +4 more
doaj   +2 more sources

Factors Associated With Sinoatrial Reinnervation After Heart Transplantation

Transplantation Direct, 2023
Background. Factors associated with sympathetic and parasympathetic sinoatrial reinnervation after heart transplantation (HTx) are inadequately studied. Methods.
Anders H. Christensen, MD, Vegard B.B. Wyller, MD, PhD, Sissel Nygaard, MD, PhD, Katrine Rolid, PT, PhD, Kari Nytrøen, PT, PhD, Lars Gullestad, MD, PhD, Arnt Fiane, MD, PhD, Erik Thaulow, MD, PhD, J. Philip Saul, MD, Gaute Døhlen, MD, PhD   +9 more
doaj   +1 more source

Brain-Derived Neurotrophic Factor Is an Important Therapeutic Factor in Mesenchymal Stem Cell Secretions for Treatment of Traumatic Peripheral Pelvic Injuries

Frontiers in Cellular Neuroscience, 2022
Traumatic neuromuscular injury to the pudendal nerve and urethra during childbirth does not regenerate well and contributes to stress urinary incontinence in women.
Xiaoyi Yuan, Xiaoyi Yuan, Xiaoyi Yuan, Brian M. Balog, Brian M. Balog, Brian M. Balog, Dan Li Lin, Dan Li Lin, Brett Hanzlicek, Brett Hanzlicek, Mei Kuang, Hao Yan, Hao Yan, Steve J. A. Majerus, Margot S. Damaser, Margot S. Damaser, Margot S. Damaser   +16 more
doaj   +1 more source

Clinical applications of electrical stimulation for peripheral nerve injury: a systematic review

Frontiers in Neuroscience, 2023
IntroductionPeripheral nerve injuries are common neurologic injuries that are challenging to treat with current therapies. Electrical stimulation has been shown to accelerate reinnervation and enhance functional recovery.
Meredith C. Costello, Emily L. Errante, Emily L. Errante, Taylor Smartz, Wilson Z. Ray, Allan D. Levi, Allan D. Levi, Stephen Shelby Burks, Stephen Shelby Burks   +8 more
doaj   +1 more source

4-Aminopyridine Induces Nerve Growth Factor to Improve Skin Wound Healing and Tissue Regeneration

Biomedicines, 2022
The discovery of ways to enhance skin wound healing is of great importance due to the frequency of skin lesions. We discovered that 4-aminopyridine (4-AP), a potassium channel blocker approved by the FDA for improving walking ability in multiple ...
Mashanipalya G. Jagadeeshaprasad, Prem Kumar Govindappa, Amanda M. Nelson, Mark D. Noble, John C. Elfar   +4 more
doaj   +1 more source

Ipidacrine efficacy in diabetic polyneuropathy complex treatment: A review

Consilium Medicum, 2022
Diabetic polyneuropathy (DPN) is a common neurological complication of diabetes mellitus. The most common DPN type is distal symmetric, predominantly sensory, polyneuropathy (DSPN), often accompanied by pain syndrome. This article is aimed to evaluate of
Olga E. Zinovyeva, Pavel D. Egorov, Anna I. Penkina, Samir S. Guseinov   +3 more
doaj   +1 more source

Denervation-Related Neuromuscular Junction Changes: From Degeneration to Regeneration

Frontiers in Molecular Neuroscience, 2022
Neuromuscular junctions (NMJs) are the key interface between terminal nerves and targeted muscle, which undergo degeneration during denervation periods. Denervation-related NMJs changes limits the recovery level of nerve repair strategies.
Xinying Huang, Xinying Huang, Xinying Huang, Xinying Huang, Junjian Jiang, Junjian Jiang, Junjian Jiang, Jianguang Xu, Jianguang Xu, Jianguang Xu   +9 more
doaj   +1 more source

The Curious Anti-Pathology of the Wlds Mutation: Paradoxical Postsynaptic Spine Growth Accompanies Delayed Presynaptic Wallerian Degeneration

Frontiers in Molecular Neuroscience, 2021
The Wlds mutation, which arose spontaneously in C57Bl/6 mice, remarkably delays the onset of Wallerian degeneration of axons. This remarkable phenotype has transformed our understanding of mechanisms contributing to survival vs. degeneration of mammalian
Oswald Steward, Oswald Steward, Oswald Steward, Oswald Steward, Oswald Steward, Jennifer M. Yonan, Jennifer M. Yonan, Paula M. Falk   +7 more
doaj   +1 more source

Age-induced muscle atrophy and increase in fatigue resistance

Journal of Physical Fitness and Sports Medicine, 2014
A number of changes occur with aging in skeletal muscles including a reduction in muscle fiber size and fiber number. However, recent studies have indicated that the elderly tend to be more resistant to fatigue than the young, particularly during ...
Shinya Masuda, Hisashi Takakura, Hisashi Kato, Tetsuya Izawa   +3 more
doaj   +1 more source

Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS

eLife, 2018
Despite being an early event in ALS, it remains unclear whether the denervation of neuromuscular junctions (NMJ) is simply the first manifestation of a globally degenerating motor neuron.
Éric Martineau, Adriana Di Polo, Christine Vande Velde, Richard Robitaille   +3 more
doaj   +1 more source