Results 191 to 200 of about 61,364 (309)

Redox‐regulated signalling of adaptations to contractile activity in skeletal muscle: Implications for age‐related muscle weakness

Experimental Physiology, EarlyView.
Abstract Skeletal muscle adaptation to contractile activity is modulated by redox signalling, primarily through reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Early research framed ROS as deleterious byproducts of exercise, but subsequent studies have established their roles as signalling molecules involved in mitochondrial biogenesis,
Malcolm J. Jackson
wiley   +1 more source

Repositioning renal denervation in resistant hypertension: evidence-based insights, stratified decision-making, and implementation pathways. [PDF]

Front Cardiovasc Med
Li M, Yang D, Cheng X, Wei Q, Zhang D.
europepmc   +1 more source

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

Experimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova, Evgenii Lysenko, Fabio Sarto, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +6 more
wiley   +1 more source

The other half of the sprinting coin: the neuromuscular profile of a 91-yr-old female world record sprinter. [PDF]

J Appl Physiol (1985)
Colosio M, Dobrzycki I, Teigen LE, Carbonaro M, Ansaldo M, Gatti M, Brusco CM, Canepari M, Bottinelli R, Botter A, Porcelli S, Franchi MV, Sundberg CW.   +12 more
europepmc   +1 more source

STUDIES IN DENERVATION: A.--METHODS [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1943
openaire   +2 more sources

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Efficacy and safety of extravascular renal denervation in patients with resistant hypertension: a study protocol for a pilot, single-arm, multi-center, first-in-human study. [PDF]

Clin Hypertens
Yoon M, Kim HK, Han JH, Kim HJ, Jeong CW, Choi DJ.   +5 more
europepmc   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

WAT-to-BAT communication facilitates the sustained activation of BAT thermogenesis during cold exposure. [PDF]

Cell Discov
Xue J, Chen D, Wang C, Wang J, Zhou J, Li W, Qian J, Huang Y, Fang L, Song H, He B, Zhao XY.   +11 more
europepmc   +1 more source

Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans

Experimental Physiology, EarlyView.
Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin, Jean‐Christophe Lagacé, Mathil Ruel, Ahmed Ghachem, Guillaume Léonard, Eleonor Riesco, Mathew Piasecki, Jamie S. McPhee, Isabelle J. Dionne   +8 more
wiley   +1 more source