Results 31 to 40 of about 129,742 (214)

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

First Outbreak of Dengue Hemorrhagic Fever, Bangladesh

Emerging Infectious Diseases, 2002
During the first countrywide outbreak of dengue hemorrhagic fever in Bangladesh, we conducted surveillance for dengue at a hospital in Dhaka. Of 176 patients, primarily adults, found positive for dengue, 60.2% had dengue fever, 39.2% dengue hemorrhagic ...
Mahbubur Rahman, Khalilur Rahman, A. K. Siddque, Shereen Shoma, A. H. M. Kamal, K. S. Ali, Ananda Nisaluk, Robert F. Breiman   +7 more
doaj   +1 more source

Penilian Kinerja Tenaga Survailans Kesehatan (Gasurkes) Demam Berdarah Dengue (Dbd) Di Kecamatan Tembalangkota Semarang [PDF]

, 2017
Dengue Hemorrhagic Fever is the one of the most endemic disease in Indonesia. One of the biggest city in Indonesia, Semarang, turn out to be the one of the most dengue fever patient every years.. In Peraturan Walikota Kota Semarang No.
Wardayani, M. O. (Mirsa), Widowati, N. (Nina)   +1 more
core  

Climatic conditions : conventional and nanotechnology-based methods for the control of mosquito vectors causing human health issues [PDF]

, 2019
Climate variability is highly impacting on mosquito-borne diseases causing malaria and dengue fever across the globe. Seasonal variability change in temperature and rainfall patterns are impacting on human health.
Ahmed, Toqeer,, Hyder, Muhammad Zeeshan,, Liaqat, Irfan,, Lund University., Scholz, Miklas,   +4 more
core   +2 more sources

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Myopericarditis - A catastrophic complication of dengue fever

Journal of Family Medicine and Primary Care, 2022
Dengue is a mosquito-borne viral fever seen commonly in the urban areas of tropical and sub-tropical countries. The spectrum of this disease varies from a simple fever which can be managed with anti-pyretics to dengue shock syndrome, which requires ...
Anamika Giri, Sourya Acharya, Sandeep Kamat, Samarth Shukla, Sunil Kumar   +4 more
doaj   +1 more source

Detection of Insecticide Resistance in Aedes Aegypti to Organophosphate in Pulogadung, East Jakarta [PDF]

, 2015
Dengue Hemorrhagic Fever (DHF) is a major public health problem in Indonesia. Jakarta is a capital city with the highest number of dengue patients. Among sporadic endemic areas in Jakarta, Pulogadung, a district of East Jakarta, is one of endemic areas ...
Donanti, E. (Elita), Hardjanti, A. (Ambar), Indrawati, I. (Isna), Wibowo, H. (Heri), Zulhasril, Z. (Zulhasril)   +4 more
core  

Analysis of Gene Expression in Aedes aegypti Suggests Changes in Early Genetic Control of Mosquito Development

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
ABSTRACT Aedes aegypti, a critical vector for tropical diseases, poses significant challenges for studying its embryogenesis due to difficulties in removing its rigid chorion and achieving effective fixation for in situ hybridization. Here, we present novel methodologies for fixation, dechorionation, DAPI staining, and in situ hybridization, enabling ...
Renata Coutinho‐dos‐Santos, Danielle Santos, Lupis Ribeiro, Jonathan J. Mucherino‐Muñoz, Marcelle Uhl, Carlos Logullo, A. Mendonça‐Amarante, M. Fantappie, Rodrigo Nunes‐da‐Fonseca   +8 more
wiley   +1 more source

The Significance of Prolonged and Saddleback Fever in Hospitalised Adult Dengue.

PLoS ONE, 2016
Dengue fever is gaining importance in Singapore with an increase in the number of cases and mortality in recent years. Although prolonged and saddleback fever have been reported in dengue fever, there are no specific studies on their significance in ...
Deborah Hl Ng, Joshua Gx Wong, Tun-Linn Thein, Yee-Sin Leo, David C Lye   +4 more
doaj   +1 more source

Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents

Pest Management Science, EarlyView.
A two‐pronged screen of small molecules – (1) on recombinant kinin receptor and (2) through topical application – identifies kinin receptor antagonists, feeding behavior modulators, and new mosquitocidal molecules. Abstract BACKGROUND Aedes aegypti and Culex quinquefasciatus mosquitoes are primary vectors for numerous human and animal pathogens and ...
Bianca M. Henriques‐Santos, Patricia V. Pietrantonio   +1 more
wiley   +1 more source