Results 51 to 60 of about 82,510 (260)

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Myopericarditis - A catastrophic complication of dengue fever

Journal of Family Medicine and Primary Care, 2022
Dengue is a mosquito-borne viral fever seen commonly in the urban areas of tropical and sub-tropical countries. The spectrum of this disease varies from a simple fever which can be managed with anti-pyretics to dengue shock syndrome, which requires ...
Anamika Giri, Sourya Acharya, Sandeep Kamat, Samarth Shukla, Sunil Kumar   +4 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism [PDF]

, 2005
Background: Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is associated with increased PAI-1 ...
ten Cate, H, Brandjes, DPM, Mairuhu, A. T. A., Hack, C. E., Leyte, A, Osterhaus, A.D.M.E. (Albert), Koraka, P. (Penelope), Brandjes, D.P.M. (Dees), Mairuhu, A.T., ten Cate H, Brandjes, D.P., SMH Faradz, Faradz, S.M.H., van Gorp, E., Hack, C. Erik, Setiati, T., Brandjes DPM, Mairuhu, ATA, Osterhaus ADME, Setiati, T. E., Reitsma, PH, Osterhaus, A.D.M.E., Faradz, SMH, Faradz SMH, Gorp, E. van, Brandjes, D. P. M., van Gorp, E. C. M., Faradz, Sultana M.H., Setiati, T.E. (Tatty), Brandjes, D.P.M., Osterhaus, A.D., Setiati, Tatty E., van Gorp, E.C.M., Cate, H. (Hugo) ten, Koraka, P., Reitsma PH, van Gorp, Eric, Mairuhu, A.T.A., Mairuhu ATA, Reitsma, P., ECM van Gorp, Koraka, Penelopie, Reitsma, P.H., A Leyte, Setiati, TE, van Gorp, Eric C. M., Setiati TE, Osterhaus, Ab, Koraka, P, Leyte A, H ten Cate, ADME Osterhaus, Osterhaus, A. D. M. E., Hack CE, PH Reitsma, Setiati, T.E., Hack, C.E., Osterhaus, ADME, Faradz, S. M. H., CE Hack, Reitsma, P. H., van Gorp ECM, ATA Mairuhu, Osterhaus, A., TE Setiati, Koraka P, Leyte, A. (Anja), P Koraka, Mairuhu, A., Faradz, S.M.H. (Sultana), Gorp, E.C.M. (Eric) van, Hack, CE, DPM Brandjes, Hack, C., Faradz, S., Cate, H. Ten, Hack, C.E. (Erik), ten Cate, H., Leyte, A.   +78 more
core   +1 more source

The Significance of Prolonged and Saddleback Fever in Hospitalised Adult Dengue.

PLoS ONE, 2016
Dengue fever is gaining importance in Singapore with an increase in the number of cases and mortality in recent years. Although prolonged and saddleback fever have been reported in dengue fever, there are no specific studies on their significance in ...
Deborah Hl Ng, Joshua Gx Wong, Tun-Linn Thein, Yee-Sin Leo, David C Lye   +4 more
doaj   +1 more source

Analysis and Simulation of SIRS Model for Dengue Fever Transmission in South Sulawesi, Indonesia

Journal of Applied Mathematics, 2021
This study is aimed at building and analysing a SIRS model and also simulating the model to predict the number of dengue fever cases. Methods applied for this model are building the SIRS model by modifying the SIR model, analysing the SIRS model using ...
Wahidah Sanusi, Nasiah Badwi, Ahmad Zaki, Sahlan Sidjara, Nurwahidah Sari, Muhammad Isbar Pratama, Syafruddin Side   +6 more
doaj   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Towards understanding of the replication and pathogenesis of dengue infection [PDF]

, 2007
Dengue is the most important human viral disease transmitted by arthropod vectors and over half of the world's population live in areas at risk of infection. Currently there is neither specific treatment nor vaccine to tackle this emerging disease. The
Umareddy, Indira
core   +1 more source

Incidence of dengue illness among children in an urban setting in South India: A population based study

International Journal of Infectious Diseases, 2019
Objectives: Our main objective was to estimate population based dengue incidence estimates in children with fever >3 days. Methods: The study used the ‘National Surveillance System for Enteric Fever in India’ (NSSEFI) cohort at the Vellore site. Children
Winsley Rose, Kulandaipalayam Natarajan Sindhu, Asha Mary Abraham, Gagandeep Kang, Jacob John   +4 more
doaj   +1 more source

Pearl's causality for integrating ecological datasets: A case study on Myricaria germanica in northern Italy

Applications in Plant Sciences, EarlyView.
Abstract Premise Applied ecology can significantly influence policy decisions on environmental issues. Therefore, research in this field should be as transparent and reproducible as possible. Existing expertise from a broad range of disciplines should also be integrated into ecological research to allow researchers to maximize understanding of complex ...
Kailin Weitkämper, Kilian Rückschloß, Tommaso Sitzia, Bruno Michielon, Silke Werth, Felix Weitkämper   +5 more
wiley   +1 more source