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Advances in dengue vaccine development
Human Vaccines, 2009Dengue viruses are the most important arboviruses causing human disease. Expansion of the disease in recent decades to include more geographical areas of the world, an appreciation of the disease burden and market potentials have spurred a flurry of activity in the development of vaccines to combat dengue viruses.
Kanakatte, Raviprakash +3 more
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This chapter offers an overview of dengue vaccines that have advanced to clinical trials, addressing the intricate challenges in their development. It details the complexities of the dengue virus, including its four serotypes and the phenomenon of antibody-dependent enhancement (ADE), which significantly impacts vaccine design.
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The Southeast Asian journal of tropical medicine and public health, 2015
The uniqueness of the dengue viruses (DENVs) and the spectrum of disease resulting from infection have made dengue vaccine development difficult. Several vaccine candidates are currently being evaluated in clinical studies. The candidate currently at the most advanced clinical development stage, a live-attenuated tetravalent vaccine based on the ...
Usa, Thisyakorn, Chule, Thisyakorn
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The uniqueness of the dengue viruses (DENVs) and the spectrum of disease resulting from infection have made dengue vaccine development difficult. Several vaccine candidates are currently being evaluated in clinical studies. The candidate currently at the most advanced clinical development stage, a live-attenuated tetravalent vaccine based on the ...
Usa, Thisyakorn, Chule, Thisyakorn
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Dengue Virus Vaccine Development
2014Dengue virus (DENV) is a significant cause of morbidity and mortality in tropical and subtropical regions, causing hundreds of millions of infections each year. Infections range from asymptomatic to a self-limited febrile illness, dengue fever (DF), to the life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).
Lauren E, Yauch, Sujan, Shresta
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2006
Dengue is an expanding health problem. About two-fifths of the world population are at risk for acquiring dengue with 50-100 million cases of acute febrile illness yearly including about 500,000 cases of DHF/DSS. No antiviral drugs active against the flavivirus exist. Attempts to control mosquito vector has been largely unsuccessful.
Sriluck, Simasathien +1 more
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Dengue is an expanding health problem. About two-fifths of the world population are at risk for acquiring dengue with 50-100 million cases of acute febrile illness yearly including about 500,000 cases of DHF/DSS. No antiviral drugs active against the flavivirus exist. Attempts to control mosquito vector has been largely unsuccessful.
Sriluck, Simasathien +1 more
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Dengue vaccines: preparing to roll back dengue.
Current opinion in investigational drugs (London, England : 2000), 2003Dengue is an emerging viral pathogen of growing global importance, infecting up to 100 million people annually. Although there have been many efforts over the last six decades to produce a vaccine to combat this infection, few have been able to meet the challenges posed by the unusual interplay between this virus and its human host.
Jacobs, M., Young, P. R.
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Nihon rinsho. Japanese journal of clinical medicine, 2011
Dengue fever is the most important mosquito-borne viral disease in the world, for which preventive vaccines are urgently required. Several strategies have been used for dengue tetravalent vaccine development. Strategies with traditional attenuation, chimerization, engineered attenuation are in the more advanced stages. In addition, inactivated, subunit,
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Dengue fever is the most important mosquito-borne viral disease in the world, for which preventive vaccines are urgently required. Several strategies have been used for dengue tetravalent vaccine development. Strategies with traditional attenuation, chimerization, engineered attenuation are in the more advanced stages. In addition, inactivated, subunit,
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Targets and strategies for vaccine development against dengue viruses
Biomedicine and Pharmacotherapy, 2021Wen-Hung Wang +2 more
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