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Dengue infection and advances in dengue vaccines for children
The Lancet Child & Adolescent Health, 2019Dengue viruses are endemic in most tropical and subtropical countries where they produce disease ranging from a mild fever to a severe, potentially fatal vascular permeability syndrome. We reviewed the status of development and testing in children of three vaccines designed to protect against the four dengue viruses.
Scott B, Halstead, Leonila F, Dans
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Introducing dengue vaccine: Implications for diagnosis in dengue vaccinated subjects
Vaccine, 2016Diagnosis of dengue virus infections is complicated by preference for different diagnostic tests in different post onset days of illness and the presence of multiple serotypes leading to secondary and tertiary infections. The sensitivity of the most commonly employed diagnostic assays such as anti dengue IgM capture (MAC) ELISA and non structural ...
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Advancing dengue vaccine development
Science, 2017Insights into the natural history of dengue virus infection guide vaccine ...
Mark B, Feinberg, Rafi, Ahmed
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Dengue vaccines: state of the art
Expert Opinion on Therapeutic Patents, 2010Dengue is a significant public health problem transcending geographical boundaries to place nearly 50% of the global population at risk. A vaccine to prevent dengue is an unmet need that should be addressed urgently.A brief introduction to dengue and a detailed review of the classical and modern approaches being undertaken currently to develop dengue ...
Sathyamangalam, Swaminathan +2 more
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Advances in dengue vaccine development
Human Vaccines, 2009Dengue viruses are the most important arboviruses causing human disease. Expansion of the disease in recent decades to include more geographical areas of the world, an appreciation of the disease burden and market potentials have spurred a flurry of activity in the development of vaccines to combat dengue viruses.
Kanakatte, Raviprakash +3 more
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This chapter offers an overview of dengue vaccines that have advanced to clinical trials, addressing the intricate challenges in their development. It details the complexities of the dengue virus, including its four serotypes and the phenomenon of antibody-dependent enhancement (ADE), which significantly impacts vaccine design.
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The Southeast Asian journal of tropical medicine and public health, 2015
The uniqueness of the dengue viruses (DENVs) and the spectrum of disease resulting from infection have made dengue vaccine development difficult. Several vaccine candidates are currently being evaluated in clinical studies. The candidate currently at the most advanced clinical development stage, a live-attenuated tetravalent vaccine based on the ...
Usa, Thisyakorn, Chule, Thisyakorn
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The uniqueness of the dengue viruses (DENVs) and the spectrum of disease resulting from infection have made dengue vaccine development difficult. Several vaccine candidates are currently being evaluated in clinical studies. The candidate currently at the most advanced clinical development stage, a live-attenuated tetravalent vaccine based on the ...
Usa, Thisyakorn, Chule, Thisyakorn
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Dengue Virus Vaccine Development
2014Dengue virus (DENV) is a significant cause of morbidity and mortality in tropical and subtropical regions, causing hundreds of millions of infections each year. Infections range from asymptomatic to a self-limited febrile illness, dengue fever (DF), to the life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).
Lauren E, Yauch, Sujan, Shresta
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2006
Dengue is an expanding health problem. About two-fifths of the world population are at risk for acquiring dengue with 50-100 million cases of acute febrile illness yearly including about 500,000 cases of DHF/DSS. No antiviral drugs active against the flavivirus exist. Attempts to control mosquito vector has been largely unsuccessful.
Sriluck, Simasathien +1 more
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Dengue is an expanding health problem. About two-fifths of the world population are at risk for acquiring dengue with 50-100 million cases of acute febrile illness yearly including about 500,000 cases of DHF/DSS. No antiviral drugs active against the flavivirus exist. Attempts to control mosquito vector has been largely unsuccessful.
Sriluck, Simasathien +1 more
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