Results 71 to 80 of about 754,759 (237)

Humanized mice in dengue research: a comparison with other mouse models [PDF]

, 2020
: Dengue virus (DENV) is an arbovirus of the Flaviviridae family and is an enveloped virion containing a positive sense single-stranded RNA genome. DENV causes dengue fever (DF) which is characterized by an undifferentiated syndrome accompanied by fever,
Jaime E. Castellanos, Medina-Moreno, Sandra M., Hernando Gutiérrez-Barbosa, Myriam L. Velandia-Romero, Corolnel-Ruíz, Carolina, Velandia-Romero, Myriam Lucía, Castellanos, Jaime, Juan C. Zapata, Chua, Joel, Sandra Medina-Moreno, Gutiérrez Barbosa, Hector Hernando, Zapata, Juan, Carolina Coronel-Ruiz, Joel V. Chua   +13 more
core   +1 more source

Dengue vaccine endgame: why has the global response to exponential demand in the tropics been so slow?

Frontiers in Tropical Diseases
IntroductionThere has been a dramatic global surge in dengue fever (DF) in recent years, with a projected 100-400 million cases annually and large outbreaks expected every 3-4 years.
Cristina Possas, Ernesto T. A. Marques, Ernesto T. A. Marques, Alessandra Oliveira, Suzanne Schumacher, Adelaide Antunes, Adelaide Antunes, Akira Homma   +7 more
doaj   +1 more source

Biological view of vaccination described by mathematical modellings: from rubella to dengue vaccines.

Mathematical biosciences and engineering : MBE, 2019
The only rubella vaccine available in North America is the RA27/3 strain (isolated from the kidney of a rubella-infected fetus and attenuated) licensed in 1979, which substituted HPV77/DE5 strain vaccine due to concerns about waning immunity.
Mo Yang, A. R. Freitas
semanticscholar   +1 more source

NS1 Protein N-Linked Glycosylation Site Affects the Virulence and Pathogenesis of Dengue Virus

Vaccines, 2023
Live attenuated vaccine is one of the most effective vaccines against flavivirus. Recently, site-directed mutation of the flavivirus genome using reverse genetics techniques has been used for the rapid development of attenuated vaccines.
Enyue Fang, Miao Li, Xiaohui Liu, Kongxin Hu, Lijuan Liu, Zelun Zhang, Xingxing Li, Qinhua Peng, Yuhua Li   +8 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Dengue Fever Epidemics and the Prospect of Vaccines: A Systematic Review and Meta-Analysis Using Clinical Trials in Children

Diseases
About half of the world’s population is at risk of dengue infection. Epidemics of dengue fever have caused an increased risk of morbidity and mortality in recent years, which led to the exploration of vaccines as a preventive measure.
Ebele C. Okoye, Amal K. Mitra, Terica Lomax, Cedric Nunaley   +3 more
doaj   +1 more source

Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus

Scientific Reports, 2021
Dengue poses a global health threat, which will persist without therapeutic intervention. Immunity induced by exposure to one serotype does not confer long-term protection against secondary infection with other serotypes and is potentially capable of ...
Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi, Darius Riziki Martin, Mediline Goboza, Ashwil Klein, Abram Madimabe Madiehe, Mervin Meyer   +6 more
doaj   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

British National Formulary Guidance on prescribing in pregnancy: A descriptive cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aim To assess how well pregnancy‐specific guidance within the British National Formulary supports healthcare professionals to facilitate safe and effective medication use. Methods We performed a manifest content analysis of the text of all pregnancy sections within British National Formulary drug monographs, with inductive and iterative coding.
Hannah Johnson, Cleodie Swire, Lakshiv Dhingra, Toqa El‐Nahhas, Michelle Essiam, Salma Muse, Maria Tonkova, Nazmin Begum, Joan Morris, Emma Baker   +9 more
wiley   +1 more source

Decentralisation of the Healthcare Systems and the Functioning of Public Health Programmes in Single‐Party States: A Systematic Review

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Introduction Decentralisation is the transfer of authority from central to local governments, involving shared responsibilities in planning, management, and decision‐making. In public health, decentralisation might help improve service delivery by allowing local authorities to tailor interventions to the specific needs of diverse ...
Phonevilay Viphonephom, Ho Van Hoa, Sengchanh Kounnavong, Daniel Reinharz   +3 more
wiley   +1 more source