Results 141 to 150 of about 1,391,312 (259)

Enteric Fever Presenting With Acute Bilateral Lower Limb Weakness due to Para Infectious Myopathy With Elevated Serum Creatine Kinase: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Parainfectious myopathy is a rare complication of Salmonella infection. We report an immunocompetent young patient presenting with acute bilateral lower limb weakness and markedly elevated creatine kinase. Blood cultures confirmed Salmonella sp. Prompt treatment with meropenem and azithromycin resulted in reducing CK level from 1854 to 240 U/L.
Shahbaz Khan, Talha Farooq, Syeda Fatiha Hussain, Rooma Rehan, Kainat Usman, Hammad Iftikhar, Hamna Hassan Siddiqui, Muhammad Kamal, Hammad Khan, Abbas Sikandar, Somaiya Ahmed   +10 more
wiley   +1 more source

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1379-1388, November 2026.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

The Evolution of Dengue Virus in India

Annual Review of Virology
The evolution of dengue virus (DENV) is highly modulated by pathogen transmission bottlenecks and immunological pressures. These evolutionary events lead to mutations that cause antigenic changes and the replacement of DENV genotypes, which are directly correlated with epidemic magnitude and severe disease.
openaire   +2 more sources

Synthesis, Cytotoxic Activity, mRNA Expression, Total Oxidant and Antioxidant Status, and Molecular Modeling Studies of Novel Schiff Base–Thiosemicarbazone Hybrids

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In this study, new Schiff base‐derived compounds were synthesized, and their structures were confirmed by FT‐IR, 1H‐NMR, 13C‐NMR, and HRMS analyses. The cytotoxic effects of the compounds on a prostate cancer cell line (PC3) were investigated, and it was determined that the compounds NZ10, NZ9, NZ7, and NZ4, in particular, exhibited potent anticancer ...
Anber M Anber, Mehmet Özbay, İlhan Özer İlhan, Hüseyin Kekeçmuhammed, Rıfat Emin Bora, Emin Saripinar, Yalçın Erzurumlu, Muhammed Tilahun Muhammed, Sadeq K. Alhag, Lamya Ahmed Alkeridis, Senem Akkoc   +10 more
wiley   +1 more source

UHPLC‐DAD‐HRMS2 Characterization of Novel Dihydrochalcone Conjugates From the Antiviral Mansoa hirsuta Extracts: Diagnostic Fragmentation Pathways and Dereplication of Oligomeric Polyphenols

Journal of Mass Spectrometry, Volume 61, Issue 11, November 2026.
ABSTRACT High‐resolution mass spectrometry (HRMS) coupled with ultra‐high‐performance liquid chromatography (UHPLC) enables rapid characterization of complex polyphenolic constituents in medicinal plants. Mansoa hirsuta (Bignoniaceae), a neotropical liana traditionally used to treat infectious diseases, remains poorly characterized chemically.
Adriana Cotta Cardoso Reis, Breno de Mello Silva, Cíntia Lopes de Brito Magalhães, Erna G. Kroon, Douglas da Costa Gontijo, Markus Kohlhoff, Geraldo Célio Brandão   +6 more
wiley   +1 more source

Introduction and Spread of West Nile Virus in Lazio, Italy, 2025: Molecular Epidemiology and Genomic Characterization

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT West Nile virus (WNV) is a flavivirus whose cycle involves mosquitoes and avian hosts that occasionally may infect horses and humans as “dead‐end hosts.” Human infection is mostly asymptomatic, sometimes leading to febrile or neuroinvasive disease.
Martina Rueca, Cesare Ernesto Maria Gruber, Gabriella De Carli, Ilaria Mussetto, Carla Nartuhi Mavian, Giuseppe Manna, Francesca Rosone, Davide La Rocca, Juan Guillermo Perez‐Jimenez, Maria Teresa Scicluna, Giovanni Chillemi, Eliana Specchiarello, Francesca Colavita, Flavia Smoquina, Alessandra Nappo, Christina Merakou, Marcello Giovanni Sala, Claudio De Liberato, Giulietta Venturi, Andrea Siddu, Francesco Vairo, Fabrizio Maggi, Fabrizio Carletti   +22 more
wiley   +1 more source

Therapeutic and Prophylactic Agents for Viral Diseases: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 11, November 2026.
This review summarizes current therapeutic and prophylactic strategies for global viral diseases, including vaccines, PrEP, direct‐acting antivirals, and emerging modalities such as CRISPR and siRNA. It highlights their clinical impact, ongoing challenges, and future priorities toward broader protection, improved delivery, and more effective antiviral ...
Sawar Khan, Ayesha Nisar, Xiaoxu Li, Hao Yu, Abdul Qadeer, Sardar Azhar Mehmood, Imane Lamraoui, Sijie Liu, Lipeng Zhu, Xu Deng, Bo Kong, Kejun Zhong, Zanxian Xia   +12 more
wiley   +1 more source

Prevention of Dengue Virus Infection

Saudi Journal of Medicine & Medical Sciences, 2017
Idris-Abdullahi Nasir, Mustapha Bakare, Omoare A Ayodeji, Abdurrahman Ahmad, Ibrahim M Hamidu   +4 more
openaire   +3 more sources

Mitochondria in Viral Infections: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 11, November 2026.
Viral infections remodel mitochondrial function through direct viral regulation and infection‐induced changes in host cellular processes. These alterations affect OXPHOS, mitochondrial metabolism, calcium homeostasis, membrane potential, redox regulation, dynamics, and apoptosis, with distinct effects on viral replication and host antiviral responses ...
Ha Young Oh, Hye Jin Shin
wiley   +1 more source

Metabolic Screening and In Silico Investigation of Eucalyptus globulus Essential Oil Bioactives Against DENV‐2 Envelope Protein

ChemistryOpen, Volume 15, Issue 11, November 2026.
Network pharmacology and molecular docking identify bioactive compounds from Eucalyptus globulus essential oil with potential activity against dengue virus, highlighting 70 shared targets and DENV‐2‐associated pathways. Globulol and eucalyptol show strong binding to DENV‐2 receptors, with favorable drug‐likeness and toxicity profiles, supporting their ...
Arslan Afzal, Ilyas Ahmad, Mahadullah, Saliha Qamar, Tayyaba Yousaf, Faiz Ullah, Dilawar Khan, Mohammad Hamid Hamdard, Zia ur Rehman Mashwani   +8 more
wiley   +1 more source