Results 51 to 60 of about 7,980 (172)

REVIEW ARTICLE: DEVELOPEMENT AND USING DENGUE VACCINE FOR DENGUE INFECTION VIRUS

Medical and Health Science Journal, 2019
: Tropical and subtropical countries are regions with high incidence of dengue infection. Dengue virus infection is estimated to cause 300 million new infections in one year and approximately 1 million severe cases with 2 + 5% deaths.
Firdaus Kabiru Massey, Rika Yulia
doaj   +1 more source

The Medicinal Chemistry of Dengue Virus [PDF]

Journal of Medicinal Chemistry, 2016
The dengue virus and related flaviviruses are an increasing global health threat. In this perspective, we comment on and review medicinal chemistry efforts aimed at the prevention or treatment of dengue infections. We include target-based approaches aimed at viral or host factors and results from phenotypic screenings in cellular assay systems for ...
Mira A M, Behnam, Christoph, Nitsche, Veaceslav, Boldescu, Christian D, Klein   +3 more
openaire   +2 more sources

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Serotype and Clinical Performance of Dengue Virus Infection on the Year 2009

Indonesian Journal of Tropical and Infectious Disease, 2010
Dengue hemorrhagic fever is one of the important health problem in Indonesia, mortality rate is becoming decrease but many dengue shock syndrome cases is very difficult to be help.
Soegeng Soegijanto, Widodo Darmowandowo, Amor Peraten Ginting, Atsushi Yamanaka   +3 more
doaj   +1 more source

Reciprocal tripartite interactions between the Aedes aegypti midgut microbiota, innate immune system and dengue virus influences vector competence. [PDF]

PLoS Neglected Tropical Diseases, 2012
Dengue virus is one of the most important arboviral pathogens and the causative agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome.
Jose Luis Ramirez, Jayme Souza-Neto, Rolando Torres Cosme, Jose Rovira, Alma Ortiz, Juan M Pascale, George Dimopoulos   +6 more
doaj   +1 more source

Immature Dengue Virus: A Veiled Pathogen?

PLoS Pathogens, 2010
Cells infected with dengue virus release a high proportion of immature prM-containing virions. In accordance, substantial levels of prM antibodies are found in sera of infected humans. Furthermore, it has been recently described that the rates of prM antibody responses are significantly higher in patients with secondary infection compared to those with
Rodenhuis-Zybert, I.A., Schaar, H.M. van der, Silva Voorham, J.M. da, Ende-Metselaar, H. van der, Lei, H.Y., Wilschut, J., Smit, J.M.   +6 more
openaire   +7 more sources

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Inflammasome Fuels Dengue Severity

Frontiers in Cellular and Infection Microbiology, 2020
Dengue is an acute febrile disease triggered by dengue virus. Dengue is the widespread and rapidly transmitted mosquito-borne viral disease of humans.
Gaurav Shrivastava, Paola Carolina Valenzuela Leon, Eric Calvo   +2 more
doaj   +1 more source

Economic Impact of Dengue Virus in Mexico Over One Decade: A Systematic Literature Review (2010–2020)

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background Dengue is a major mosquito‐borne viral disease worldwide, imposing significant healthcare burden on governments in countries where it is endemic, such as Mexico. This systematic review focused on studies reporting the cost of dengue in Mexico during 2010–2020.
Gilberto Sánchez‐González, Luz del C. Hernández‐Hernández, Elaine Gallagher   +2 more
wiley   +1 more source

Interactions between mosquito genetic background and Wolbachia strain affect dengue virus blocking and fitness in South American populations of Aedes aegypti.

PLoS Neglected Tropical Diseases
The mosquito Aedes aegypti is the primary vector of dengue virus, and the release of mosquitoes infected with the bacterium Wolbachia is an increasingly used strategy to reduce dengue transmission.
Suk Lan Ser, Nina L Dennington, Heather I Engler, Makael L Harris, Matthew J Jones, Frank W Avila, Eric P Caragata, Ary A Hoffmann, Rafael Maciel de Freitas, Elizabeth A McGraw   +9 more
doaj   +1 more source