Development of Dengue virus type 2 replicons capable of prolonged expression in host cells
BMC Microbiology, 2001 Background As part of a program to develop a Dengue virus vaccine which avoids the deleterious effects of antibody dependent enhancement (ADE) of infection mediated by antibodies to Dengue virus structural proteins, we have begun to investigate the ...
Dayton Andrew I +2 more
doaj +1 more source
Efficient assembly and secretion of recombinant subviral particles of the four dengue serotypes using native prM and E proteins. [PDF]
, 2009 © 2009 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
Béatrice Nal +10 more
core +6 more sources
Vitamin D—A prominent immunomodulator to prevent COVID‐19 infection
International Journal of Rheumatic Diseases, Volume 26, Issue 1, Page 13-30, January 2023., 2023 Abstract COVID‐19 remains a life‐threatening infectious disease worldwide. Several bio‐active agents have been tested and evaluated in an effort to contain this disease. Unfortunately, none of the therapies have been successful, owing to their safety concerns and the presence of various adverse effects.
Sumel Ashique +13 more
wiley +1 more source
Dengue transmission dynamics in age-structured human populations in the presence of Wolbachia [PDF]
arXiv, 2021 According to the World Health Organization the global incidence rate of dengue infections have risen drastically in recent years. It is estimated that globally the number of new infections is in the range of $100$ to $400$ million per annum. At the same time a number of recent studies reported the existence of Wolbachia strains, which inhibit dengue ...
arxiv
Increased adaptive immune responses and proper feedback regulation protect against clinical dengue [PDF]
Science Translational Medicine, American Association for the
Advancement of Science, 2017, 9 (405), pp.eaal5088, 2017 Dengue is the most prevalent arthropod-borne viral disease. Clinical symptoms of dengue virus (DENV) infection range from classical mild dengue fever to severe, life-threatening dengue shock syndrome. However, most DENV infections cause few or no symptoms.
arxiv +1 more source
Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells [PDF]
, 2017 Wolbachia are intracellular maternally inherited bacteria that can spread through insect populations and block virus transmission by mosquitoes, providing an important approach to dengue control.
Ant, Thomas H. +9 more
core +2 more sources
Inhibition of dengue virus by curcuminoids [PDF]
Antiviral Research, 2019 The dengue virus is considered to be a globally important human pathogen prevalent in tropical and subtropical regions of the world. According to a recent estimate, the disease burden due to DENV infections is ∼390 million infections per year globally in ∼100 countries including the southern US, Puerto Rico and Hawaii, resulting in nearly ∼25,000 ...
Ayyiliath M. Sajith +6 more
openaire +2 more sources
Wolbachia versus dengue: Evolutionary forecasts. [PDF]
, 2013 A novel form of biological control is being applied to the dengue virus. The agent is the maternally transmitted bacterium Wolbachia, naturally absent from the main dengue vector, the mosquito Aedes aegypti.
Bull, James J, Turelli, Michael
core +1 more source
Immunopathogenesis of Dengue Virus Infection
Journal of Biomedical Science, 2001 Dengue virus infection causes dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS), whose pathogeneses are not clearly understood. Current hypotheses of antibody-dependent enhancement, virus virulence, and IFN-gamma/TNFalpha-mediated immunopathogenesis are insufficient to explain clinical manifestations of DHF/DSS such as ...
Trai Ming Yeh +5 more
openaire +2 more sources
Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina [PDF]
, 2017 Infection by any of the four dengue virus (DENV) serotypes produces a wide spectrum of clinical illness in humans. Differences in clinical manifestation and severity have been associated with secondary heterologous infection, patient age, and virus ...
Bono, María M. +7 more
core +1 more source