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A species of enveloped and spherical viruses with a capsid with T=3 icosahedral symmetry in the Flaviviridae family and Flavivirus genus. The genome is composed of non-segmented, single-stranded, positive-sense RNA.
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The Role Activity of Complement, TNFα & IL12 in Pathogenesis Dengue Virus
Dengue Virus infection is always found in some part of the world especially South East Asia including Indonesia. The pathogenesis of Dengue Virus infection is still controversial.
Soegeng Soegijanto+3 more
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Dengue virus (DENV) is the most prevalent medically important mosquito-borne virus in the world. Upon DENV infection of a host cell, DENV nonstructural protein 1 (NS1) can be found intracellularly as a monomer, associated with the cell surface as a dimer,
Dustin R. Glasner+3 more
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The reemergence of dengue virus in Sudan
Dengue fever (DF) is a mosquito-transmitted arboviral disease caused by 1 of 4 closely related but antigenically distinct serotypes of dengue virus (DENV), DENV-1-4. The primary vector of DENV is Aedes aegypti and Aedes albopictus mosquitoes. Humans are the main carrier of the virus and the amplifying host with non-human primates plays a considerable ...
Mujahed I. Mustafa+1 more
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Development of Dengue virus type 2 replicons capable of prolonged expression in host cells
Background As part of a program to develop a Dengue virus vaccine which avoids the deleterious effects of antibody dependent enhancement (ADE) of infection mediated by antibodies to Dengue virus structural proteins, we have begun to investigate the ...
Dayton Andrew I+2 more
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Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection. DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Hemorrhage and vascular leakage are two characteristic
Hong-Ru Chen, Y. Lai, T. Yeh
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Rapid Detection and Molecular Typing of Dengue Virus by Using Multiplex-Nested-RT-PCR
world. We have evaluated the combination of one-step RT-PCR and multiplex nested PCR assays for detecting dengue viruses from clinical samples. Twelve patients were screened for the dengue virus, using a pair of primers that conserve for several ...
Nastiti Wijayanti+4 more
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Dengue is the most prevalent arthropod-borne virus affecting humans today. The virus group consists of 4 serotypes that manifest with similar symptoms. Dengue causes a spectrum of disease, ranging from a mild febrile illness to a life-threatening dengue hemorrhagic fever.
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Immunopathogenesis of Dengue Virus Infection
Dengue virus infection causes dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS), whose pathogeneses are not clearly understood. Current hypotheses of antibody-dependent enhancement, virus virulence, and IFN-gamma/TNFalpha-mediated immunopathogenesis are insufficient to explain clinical manifestations of DHF/DSS such as ...
Trai Ming Yeh+5 more
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Inhibition of dengue virus by curcuminoids [PDF]
The dengue virus is considered to be a globally important human pathogen prevalent in tropical and subtropical regions of the world. According to a recent estimate, the disease burden due to DENV infections is ∼390 million infections per year globally in ∼100 countries including the southern US, Puerto Rico and Hawaii, resulting in nearly ∼25,000 ...
Ayyiliath M. Sajith+6 more
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