Results 91 to 100 of about 35,844 (248)
Giant Cell Tumor of Bone: Documented Progression over 4 Years from Its Origin at the Metaphysis to the Articular Surface. [PDF]
, 2016 The exact location of origin for giant cell tumors of bone (GCTB) remains controversial, as lesions are not routinely imaged early but rather late when the tumor is large and clinically symptomatic.
Burke, Colin +4 more
core +4 more sources
Oral Diseases, EarlyView.ABSTRACT Introduction Medication‐Related Osteonecrosis of the Jaw (MRONJ) is a severe adverse effect of antiresorptive and antiangiogenic treatment, primarily in osteoporotic and oncologic patients. The disease is characterized by persistent jawbone necrosis that results in significant impairment of the quality of life of involved patients.
Omar Ghanaiem +2 more
wiley +1 more source
JCI Insight, 2023 Denosumab is an anti-RANKL Ab that potently suppresses bone resorption, increases bone mass, and reduces fracture risk. Discontinuation of denosumab causes rapid rebound bone resorption and bone loss, but the molecular mechanisms are unclear.
Qiang Fu +12 more
doaj +1 more source
Orthopaedic Surgery, EarlyView.The schematic diagram of the role of Denosumab and ST18/PARP1 axis in the prevention of prosthesis‐related AL. Denosumab regulates TiPs‐induced macrophage activation and osteolysis through the NF‐κB pathway and M1 polarization, with ST18 acting as a key mediator.
Zhipeng Chen +5 more
wiley +1 more source
Review of: "Simplifying the dental/periodontal management of patients with metabolic bone fragility receiving treatment with denosumab" [PDF]
, 2021 Francesco Erovigni
openalex +1 more source
Pediatric Bipolar disorder, in Malta is it under-diagnosed? [PDF]
, 2012 The objective of this retrospective study was to determine the frequency of Bipolar Disorder in children and adolescents referred to the Child Guidance Clinic (CGC), St. Luke’s Hospital, Malta, over a year.
Camilleri, Nigel +3 more
core
Current perspectives on skeletal health and cancer progression across the disease continuum in breast cancer—The role of bisphosphonates [PDF]
, 2012 Pre-clinical and clinical evidence suggest that bisphosphonates inhibit both bone resorption and cancer progression. New and updated analyses from several large, controlled studies in pre- and post-menopausal women with early stage breast cancer (BC ...
Aft, R.
core +2 more sources
Orthopaedic Surgery, EarlyView.Extraarticular Knee Joint Resection is oncologically effective but carries significant functional and complication considerations. The patellar coronal osteotomy sparing the extensor mechanism (Type‐B resection) balances oncological safety and functional preservation, especially for benign aggressive tumors.
Carmine Zoccali +7 more
wiley +1 more source
New cell lines expanding the diversity of Ewing sarcoma models
International Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff +13 more
wiley +1 more source
Kidney & Blood Pressure Research, 2019 Background: Studies in women with post-menopausal osteoporosis have shown that discontinuation of treatment with denosumab leads to an increased risk of vertebral fractures because of rebound bone turnover and rapid loss of bone mineral density (BMD ...
Claudia Kobel +4 more
doaj +1 more source