Results 111 to 120 of about 23,087 (229)

Safety and efficacy of denosumab in the treatment of pulmonary metastatic giant cell tumor of bone

, 2018
Yi Luo, Fan Tang, Yitian Wang, Yong Zhou, Li Min, Wenli Zhang, Rui Shi, Hong Duan, Chongqi Tu Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China Background: Giant cell tumor (GCT) of bone is an intermittent and locally ...
Min L, Zhang W, Tu C, Shi R, Luo Y, Wang Y, Zhou Y, Tang F, Duan H   +8 more
core  

Denosumab for prevention of fractures in postmenopausal women with osteoporosis

, 2009
Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL) that blocks its binding to RANK, inhibiting the development and activity of osteoclasts, decreasing bone resorption, and increasing bone density.
Kutilek, S, Eastell, Richard, ZOOG HP, Zanchetta J, Kutilek, S., Reid, Ian, Wang A, FREEDOM Trial, Zoog, H.B., Austin, Matthew, Delmas, PD, FREEDOM, Trial, Siddhanti S, Nuti R, Delmas, P., Wang, A., McClung MR, San Martin J, Cummings, Steven R, Siddhanti, S, Christiansen, C, Eastell, R., Siris, E.S., Zanchetta, Jose, Libanati, C., Austin, Matt, Adami, Silvano, Siris, Ethel S, Reid, Ian R, Adami, S., Zoog HB, McClung, MR, Siris, ES, Kutilek S, Cummings, S.R., Martin, JS, Delmas, Pierre, Libanati C, Cummings, SR, Austin, M., Zanchetta, J, Libanati, Cesar, Devogelaer, Jean-Pierre, McClung, Michael R, Libanati, C, Eastell, R, Christiansen C, Reid, I.R., Wang, A, Wang, Andrea, San Martin, Javier, Reid IR, Christiansen, C., Zoog, Holly B, Adami, S, Christiansen, Claus, Delmas P, Siris ES, Austin, M, Kutilek, Stepan, San, Martin J, MINISOLA, Salvatore, Cummings SR, Adami S, Austin M, Reid, IR, San Martin, J., Siddhanti, Suresh, McClung, M.R., Delmas, P, Siddhanti, S., Zoog, HB, Eastell R, Zanchetta, J.   +73 more
core   +1 more source

Denosumab Regulates Titanium Particles‐Induced Macrophages Inflammation and Osteolysis by Targeting the ST18/PARP1 Interaction

Orthopaedic Surgery
Objective This study aims to investigate the role of Denosumab and its downstream target ST18 in wear particle‐induced macrophage inflammation and osteolysis, and to explore the underlying mechanisms involved in aseptic loosening (AL) of prosthetic ...
Zhipeng Chen, Fan Yang, Yifan Yu, Junxi Chen, Jichao Ye, Yue Ding   +5 more
doaj   +1 more source

Management of severe bone loss in patients at risk of medication‐related osteonecrosis of the jaw with microsurgery and guided bone regeneration: A case study

Clinical Advances in Periodontics, Volume 16, Issue 3, Page 538-547, September 2026.
Abstract Background Medication‐related osteonecrosis of the jaw (MRONJ) is a challenging complication associated with antiresorptive medications. Its exact pathophysiology remains unclear, but dental extractions and infections are known triggers, complicating prevention, and treatment.
Pedro Franco Ferreira, José Maurício Paradella de Camargo, Lara Maria Alencar Ramos Innocentini, Ana Carolina Fragoso Motta   +3 more
wiley   +1 more source

Optimizing bone health in lymphoma survivors: denosumab superiority to alendronate for R-CHOP-like therapy (the DENOSULY phase III randomized controlled trial)

Haematologica
Glucocorticoid-induced osteoporosis (GIOP) poses a critical long-term complication for lymphoma survivors, with cumulative incidence of fractures following R-CHOP-like therapy.
Shohei Kikuchi, Eiju Negoro, Ryusuke Horaguchi, Takuma Fujihira, Yoshimi Nabe, Tomoki Minemura, Kento Ono, Yusuke Kamihara, Akinori Wada, Nam H. Dang, Yasufumi Masaki, Toshihiro Miyamoto, Takahiro Yamauchi, Tsutomu Sato   +13 more
doaj   +1 more source

Role of denosumab in the management of skeletal complications in patients with bone metastases from solid tumors

, 2012
Ursa Brown-Glaberman, Alison T StopeckUniversity of Arizona Cancer Center, Tucson, AZ, USAAbstract: Skeletal-related events (SREs) including pain, fractures, and hypercalcemia are a major source of morbidity for cancer patients with bone metastases.
Stopeck AT, Brown-Glaberman U
core  

Neoadjuvant PD‐1 Blockade Tislelizumab (BGB‐A317) in Combination With Etoposide and Platinum‐Based Chemotherapy for Limited‐Disease Small Cell Lung Cancer

MedComm, Volume 7, Issue 9, September 2026.
This study assessed neoadjuvant PD‐1 blockade plus chemotherapy in patients with resectable limited‐stage small cell lung cancer. Peri‐treatment biopsy and surgical samples were analyzed using bulk RNA sequencing and bioinformatics approaches.
Shiyue Wan, Shiqi Hu, Yilv Yan, Fenghuan Sun, Dongliang Bian, Jie Luo, Dong Xie, Wenxin He, Liang Duan, Yuming Zhu, Nan Song, Ming Liu, Hongcheng Liu, Gening Jiang, Peng Zhang   +14 more
wiley   +1 more source

Efficacy of denosumab in two cases with multiple-system atrophy and osteoporosis

, 2018
Masashi Uehara, Yukio Nakamura, Jun Takahashi, Takako Suzuki, Hiroyuki Kato Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan Background: Multiple-system atrophy (MSA) is an α-synucleinopathy with a very ...
Kato H, Suzuki T, Nakamura Y, Uehara M, Takahashi J   +4 more
core  

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, Volume 18, Issue 9, Page 1005-1015, September 2026.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

Hot Tub Lung: Misdiagnosed Hypersensitivity Pneumonitis Revealing a Mycobacterial Aetiology—A Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 9, September 2026.
Our case describes chronic daily exposure with histologic detection of rare MAC organisms, illustrating the spectrum and possible coexistence between hypersensitivity and infection, emphasising the diagnostic and therapeutic complexity of this uncommon disease.
Fadi Abualhommos, Rahaf Fetyani, Yasmeen Butt, Michael Gotway, Abeer Almajali, Jehad Azar   +5 more
wiley   +1 more source