Results 91 to 100 of about 23,087 (229)

Artificial Intelligence‐Driven Precision Bisphosphonate Therapy in Osteoporosis: Mechanisms, Clinical Applications, Risks, and Future Directions

Orthopaedic Surgery, EarlyView.
This comprehensive review integrates 17 benchmark studies to illustrate the transition of osteoporosis management toward precision medicine. The schematic highlights three key clinical applications: AI‐driven opportunistic screening from routine CTs, precision pharmacotherapy selection, and the predictive prevention of adverse events like MRONJ ...
Xiang Yao, Yicong Chao, Xiao Gu, Jingtao Peng, Jishan Yuan, Wei Shi, Fuguo Zhang, Qiwen Bao   +7 more
wiley   +1 more source

Critical appraisal of denosumab in the treatment and prevention of postmenopausal osteoporosis and bone loss in patients undergoing hormone ablation

, 2010
David L Kendler1, Kenneth Shawn Davison21Prohealth Clinical Research, University of British Columbia, Vancouver, British Columbia, Canada; 2Department of Medicine, Division of Immunology and Rheumatology, Laval University, Quebec, CanadaAbstract ...
Kenneth Shawn Davison, David L Kendler
core  

Factors affecting the efficacy of nonsurgical therapy of peri‐implantitis

Periodontology 2000, EarlyView.
Abstract Objectives and Materials and Methods This article critically reviews the current knowledge on the factors influencing the efficacy of non‐surgical therapy (NST) of peri‐implantitis, taking also advantage of the know‐how from periodontitis management.
Elena Calciolari, Federico Rivara, Nikolaos Donos, Jérôme F. Lasserre, Selena Toma   +4 more
wiley   +1 more source

Denosumab as Second-Line Treatment in Patients With Metastatic Breast Cancer: A Retrospective Descriptive Pilot Study From a Single Institution

Cancer Control
Introduction Bone metastasis in breast cancer patients can lead to poor quality of life and cause significant morbidity. First-line treatments for bone metastases include bone modifying agents that inhibit osteoclast activity to reduce bone resorption ...
Briana To, Laura E. Wright, Dureti Doto, Julie Stephans, Marilly Palettas, Kai C. Johnson, Mathew Cherian, Daniel Stover, Ashley Davenport, Margaret Gatti-Mays, Robert Wesolowski, Dionisia Quiroga, Sagar Sardesai, Gilbert Bader, Bhuvaneswari Ramaswamy, Nicole Williams   +15 more
doaj   +1 more source

Denosumab and the Rebound Effect: Current Aspects of Osteoporosis Therapy (Review)

Безопасность и риск фармакотерапии
INTRODUCTION. Osteoporosis is a leading cause of morbidity, disability, reduced quality of life, and premature mortality in the elderly population. Denosumab is a treatment for osteoporosis; however, denosumab discontinuation may cause a rebound effect ...
N. Yu. Velts, O. V. Velts, R. N. Alyautdin   +2 more
doaj   +1 more source

Denosumab cessation [PDF]

Cleveland Clinic Journal of Medicine, 2020
openaire   +2 more sources

The responses using the identified denosumab regimes.

, 2012
(a) The active osteoclast using the identified denosumab regimes. (b) The bone volume using the identified denosumab regimes. (c) The MM-cell density using the identified denosumab regimes.
Yan Wang (15435), Bo Lin (116835)
core   +1 more source

Shared molecular framework and bidirectional effects of osteoporosis on periodontal disease and dental implant therapy in the elderly

Periodontology 2000, EarlyView.
Abstract Objectives This review synthesizes evidence regarding the prevalence, epidemiological associations, and mechanistic pathways between osteoporosis, periodontal disease, and dental implant therapy. Materials and Methods A literature review was conducted to identify studies focused on: osteoporosis, periodontal disease, and dental implants ...
Samin Sirous, Jaclyn C. Chalmers, Pin‐Ying Li, Yumna Subhani, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Protective effects of zoledronate after denosumab discontinuation [PDF]

, 2021
RESUMEN : Tras suspender el tratamiento con denosumab se produce un aumento de los marcadores bioquímicos de remodelado óseo por encima de los valores de partida, conocido como “efecto rebote”.
Igea García, Ana
core  

Antiresorptive therapy influence on peri‐implant diseases: Clinical implications and osteoimmunological perspectives

Periodontology 2000, EarlyView.
Abstract Background/Aim Antiresorptive therapy represents a cornerstone in the management of osteoporosis and cancer‐related bone disease through suppression of osteoclast‐mediated bone resorption. As implant therapy becomes more common in aging populations, clinicians increasingly encounter patients receiving these medications, thus making their ...
Emilio A. Cafferata, Frank Schwarz, Reinhard Gruber   +2 more
wiley   +1 more source