Results 121 to 130 of about 23,901 (228)

Denosumab Regulates Titanium Particles‐Induced Macrophages Inflammation and Osteolysis by Targeting the ST18/PARP1 Interaction

Orthopaedic Surgery
Objective This study aims to investigate the role of Denosumab and its downstream target ST18 in wear particle‐induced macrophage inflammation and osteolysis, and to explore the underlying mechanisms involved in aseptic loosening (AL) of prosthetic ...
Zhipeng Chen, Fan Yang, Yifan Yu, Junxi Chen, Jichao Ye, Yue Ding   +5 more
doaj   +1 more source

Exercise Modulates the Osteoimmune Axis: Myokine‐Mediated Mechanisms in Diabetic Bone Disease

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 7, October 2026.
Exercise activates skeletal muscle to release myokines (irisin, acute IL‐6, IL‐15 and BAIBA) and suppress myostatin, which may help counteract T2DM‐induced hyperglycemia, AGE accumulation, chronic inflammation and osteoimmune imbalance, potentially contributing to improved bone quality and reduced fracture risk.
Chao Wu, Jun Zou, Yu Yuan
wiley   +1 more source

Optimizing bone health in lymphoma survivors: denosumab superiority to alendronate for R-CHOP-like therapy (the DENOSULY phase III randomized controlled trial)

Haematologica
Glucocorticoid-induced osteoporosis (GIOP) poses a critical long-term complication for lymphoma survivors, with cumulative incidence of fractures following R-CHOP-like therapy.
Shohei Kikuchi, Eiju Negoro, Ryusuke Horaguchi, Takuma Fujihira, Yoshimi Nabe, Tomoki Minemura, Kento Ono, Yusuke Kamihara, Akinori Wada, Nam H. Dang, Yasufumi Masaki, Toshihiro Miyamoto, Takahiro Yamauchi, Tsutomu Sato   +13 more
doaj   +1 more source

Calcium and vitamin D supplementation with 3-year denosumab treatment is beneficial to enhance bone mineral density in postmenopausal patients with osteoporosis and rheumatoid arthritis

, 2018
Takako Suzuki,1 Yukio Nakamura,1,2 Hiroyuki Kato1 1Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan; 2Department of Orthopaedic Surgery, Showa Inan General Hospital, Komagane, Japan Background: This 3-year ...
Kato H, Suzuki T, Nakamura Y
core  

Effectiveness and Safety of Pharmacological Therapy for Osteoporosis in Frail Elderly Individuals: Systematic Review and Meta‐Analysis

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Frailty and osteoporosis are interrelated conditions that predominantly affect older adults. The greater the individual's frailty, the greater the probability of suffering a fracture and the greater the risk of fractures occurring in the future. Therefore, this study aimed to verify whether anti‐fracture pharmacological therapies in
Anna Julia Lacerda Raposo Freire, Fernanda Martins Gazoni, Eduardo de Holanda Carvalho, Fânia Cristina Santos   +3 more
wiley   +1 more source

Effect of denosumab on the incidence of fractures and mortality in patients undergoing hemodialysis: A retrospective cohort study.

PLoS ONE
BackgroundPatients undergoing hemodialysis are at an elevated risk of fractures; however, substantial evidence for osteoporosis treatment in this population is lacking.
Arisa Kobayashi, Tatsuhiro Yaginuma, Kazuhiko Kato, Akio Nakashima, Ichiro Ohkido, Takashi Yokoo   +5 more
doaj   +1 more source

Nitrogen‐Based Bisphosphonate Use and Risk of Cancer in Women Aged 50 Years and Older: A National Data Linkage Study

International Journal of Cancer, Volume 159, Issue 7, Page 1669-1685, 1 October 2026.
Bisphosphonates are widely used to treat osteoporosis and to manage bone metastases in patients with breast cancer. Nitrogen‐based bisphosphonates may also broadly reduce cancer risk, but evidence remains inconsistent. This large population‐based data linkage study in women aged > 50 years found that, compared to no use of osteoporosis medicines ...
Karen M. Tuesley, Fiona Caristo, Katrina Spilsbury, Sallie‐Anne Pearson, Peter Donovan, Michael D. Coory, Christopher B. Steer, Susan J. Jordan   +7 more
wiley   +1 more source

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 26-47, October 2026.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

JMT103 versus Non‐Denosumab or Denosumab Treatment in Chinese Patients with Unresectable or Surgically Challenging Giant Cell Tumor of Bone: A Propensity Score‐Matched Comparison

Cancer Medicine
Background Giant cell tumors of bone (GCTB) are RANK/RANK‐ligand positive, progressive osteolytic tumors. There was no medical treatment for GCTB based on efficacy and safety data from Chinese patients.
Hairong Xu, Yong Zhou, Feng Wei, Yi Ding, Huachao Shan, Yongkun Yang, Weifeng Liu, Tao Jin, Yi Luo, Fan Tang, Minxun Lu, Xin He, Wenli Zhang, Shaomin Yang, Lihua Zhang, Juan Wang, Hong Li, Chongqi Tu, Xiaohui Niu   +18 more
doaj   +1 more source

Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
The immunosuppressive in OM Staphylococcus aureus employs multiple physical barriers to evade host immunity during skeletal infection, including biofilm formation on implant surfaces and necrotic bone tissues, invasion into the osteocyte lacuno‐canalicular network (OLCN), intracellular persistence within osteoblasts, osteoclasts, and osteocytes, and ...
Qingqiang Lei, Liangbin Lin, Peidong Pu, Jie Chen, Xianchao Su, Shubao Liu, Yanli Tong, Hui Yu   +7 more
wiley   +1 more source