Results 81 to 90 of about 43,902 (289)

Rebound-associated vertebral fractures after denosumab discontinuation in a lung cancer patient with bone metastases

Bone Reports, 2022
Denosumab is a commonly used antiresorptive treatment in patients with osteoporosis or solid tumours with bone metastases. Upon denosumab discontinuation, a rebound phenomenon can occur that results in an increased (vertebral) fracture risk.
Jolan Dupont, Wesley Appermans, Marian Dejaeger, Isabelle Wauters, Michaël R. Laurent, Evelien Gielen   +5 more
doaj   +1 more source

Efficacy and safety of concomitant immunotherapy and denosumab in patients with advanced non-small cell lung cancer carrying bone metastases: A retrospective chart review

Frontiers in Immunology, 2022
Background Synergistic anti-tumor effects were observed in vivo and in vitro when immune checkpoint inhibitors (ICIs) were combined with denosumab. However, the clinical benefit and safety of this synergy have not been adequately evaluated in non-small ...
Hong-Shuai Li, Siyu Lei, Jun-Ling Li, P. Xing, X. Hao, Fei Xu, Haiyan Xu, Yan Wang   +7 more
semanticscholar   +1 more source

Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporosis and fractures, and denosumab, a non‐kidney‐excreted antiresorptive medication, represents a viable alternative to bisphosphonates for osteoporosis treatment in patients with T2DM. This study aimed to investigate the association among denosumab adherence, renal
Yu‐Chuan Chang, Jian‐Chih Chen, Sung‐Yen Lin, Kun‐Der Lin, Pei‐Shan Ho, Chung‐Hwan Chen, Yin‐Chih Fu, Tien‐Ching Lee   +7 more
wiley   +1 more source

Synergistic effect between denosumab and immune checkpoint inhibitors (ICI)? A retrospective study of 268 patients with ICI and bone metastases

Journal of Bone Oncology
Background: Bone metastasis is a significant concern in advanced solid tumors, contributing to diminished patient survival and quality of life due to skeletal-related events (SREs). Denosumab (DMAB), a monoclonal antibody targeting the receptor activator
E. Mabrut, S. Mainbourg, J. Peron, D. Maillet, S. Dalle, C. Fontaine Delaruelle, E. Grolleau, P. Clezardin, E. Bonnelye, C.B. Confavreux, E. Massy   +10 more
doaj   +1 more source

65 Yaş Üstü Osteoporoz Hastalarında Denosumab ve Zoledronik Asit’in Yan Etkilerinin Karşılaştırılması

Genel Tıp Dergisi, 2021
Amaç: Osteoporoz tedavisi alan hastalarda, zoledronik asit ve denosumab kullanım oranları ile bu iki ilacın yan etkilerini karşılaştırmayı amaçladık. Gereç ve Yöntem: Çalışmamızda Ocak 2016-Aralık 2017 tarihleri arasında başvuran hastaların dosyaları ...
Rabia Bağ Soytaş, Suna Avcı, Hakan Yavuzer, Serdar Özkök, Alper Döventaş, Deniz Suna Erdinçler   +5 more
doaj   +1 more source

The Clinical Spectrum of Hypophosphatasia in Older Adults. [PDF]

Clin Case Rep
ABSTRACT Alkaline phosphatase (ALP) should be measured in older adults presenting with fragility fractures. Hypophosphatasia (HPP) should be suspected in individuals with hypophosphatasemia (low serum ALP). A correct diagnosis allows clinicians to avoid using potent antiresorptive osteoporosis medications, which are contraindicated in patients with HPP.
Valdez Navarro E, Wong EM, Tile L, Cheung AM.   +3 more
europepmc   +2 more sources

Effect of follow-up raloxifene therapy after denosumab discontinuation in postmenopausal women

Osteoporosis International, 2022
Follow-up raloxifene therapy after denosumab discontinuation resulted in a decrease in bone mass to the pre-denosumab levels and a rebound increase of bone turnover markers.
J. Ha, J. Kim, C. Jeong, Y. Lim, M. Kim, H. Kwon, Kye-Hwa Song, M. Kang, K. Baek   +8 more
semanticscholar   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

Review of: "Personalized (tailored) treatment with antiresorptive drugs (bisphosphonates, denosumab) in patients with bone metastases from solid tumors – A “Pico” document by Rete Oncologica Piemonte-Valle D’Aosta Bone Metastatic Disease Study Group" [PDF]

, 2023
Sunil Poudel
openalex   +3 more sources

Managing menopausal symptoms and associated clinical issues in breast cancer survivors [PDF]

, 2017
Objective: Review evidence to guide management of menopausal signs and symptoms in women after breast cancer and make recommendations accordingly. Evidence: Randomized controlled clinical trials, observational studies, evidence-based guidelines, and
Davis, Susan R., Gompel, Anne, Lumsden, Mary Ann, Pinkerton, JoAnn V., Santen, Richard J., Stuenkel, Cynthia A.   +5 more
core   +1 more source