Results 121 to 130 of about 7,500 (302)

Denotation: a literate institution for a small southern town

open access: yes, 1991
The usage of the paired terms of denotation and connotation are one means by which language provides for the declarative knowing of all things; denotation is a naming by means of indication, whereas connotation is that which incites the specificity of ...
Louviere, Gregory Paul
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Research on the Connotation,Denotation of the Ground Information Port

open access: yes天地一体化信息网络, 2020
In view of the existing problems in infrastructure,data sharing,application services and other aspects in China's space information application service system,the defi nition,construction concept and development goal of ground information port (GIP) was ...
Bin ZHOU   +4 more
doaj  

DENOTATION AND CONNOTATION ON ‘PATHETIC FAIRY TALE BY SAPTARASA

open access: yes, 2019
Lyrics of songs are almost similar to poetry, which distinguishes them from song lyrics that do not require deep diction to refer to majas or symbols. Therefore, many song lyrics revolve around the meaning of denotations and connotations.
Sutikno, Eka Ugi
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Semasiological measurements of phraseological units

open access: yesИзвестия Южного федерального университета: Филологические науки, 2015
The article deals with semantic relations in phraseology in modern English. In particular, the authors attempt to analyze different perspectives on the problem of correlation of concepts such as phraseological variance and synonyms existing in Russian ...
Khavpacheva Oksana Khautievna   +1 more
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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