Results 221 to 230 of about 49,575 (231)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Nonlinear compartmental modeling of COVID-19 with dual dose vaccination using Mason graphs and variational iteration method. [PDF]

Sci Rep
Ghani U, Ahmad B, Mahmood S, Flah A, Ghatasheh M, Pergl I.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Development and validation of a species-specific environmental DNA (eDNA) primer for endangered Asian arowana, Scleropages formosus (Teleostei: Osteoglossidae) for law enforcement and wild population monitoring. [PDF]

MethodsX
Mohd-Azhar NAE, Baharuddin H, Salmi MS, Ismail NF, Md Ali AS, Saidin S, Abu-Bakar A.   +6 more
europepmc   +1 more source

Development and laboratory validation of a plant-derived repellent blend, effective against Aedes aegypti [Diptera: Culicidae], Anopheles gambiae [Diptera: Culicidae] and Culex quinquefasciatus [Diptera: Culicidae]. [PDF]

PLoS One
Wood MJ, Bull JC, Kanagachandran K, Butt TM.   +3 more
europepmc   +1 more source

The Definition of the Intensivist in the Era of Global Healthcare: 2024 Consensus Statement From the Society of Critical Care Medicine Defining Intensivist Task Force. [PDF]

Crit Care Med
Wu D, Dzierba AL, Ablordeppey EA, Dorman T, Du B, Dulu AO, Gunnerson K, Holly PB, Jansen van Rensburg J, Kortz TB, Livesay SL, Lorenzo J, Madden MA, Mathur P, Myatra SN, Roberts KE, Rodríguez-Vega GM, Szakmany T, Taha A, Tisherman SA.   +19 more
europepmc   +1 more source

Cranial Defect Reconstruction With Custom 3D-Printed Hydroxyapatite Scaffolds Augmented With rhBMP-2 or Dipyridamole in a Nonhuman Primate Model. [PDF]

J Tissue Eng Regen Med
Bins GP, Burkart HA, Molair W, Kogan S, Massary DA, Pereira AC, Aksu A, Reinauer F, Couture DA, Witek L, Runyan CM.   +10 more
europepmc   +1 more source

Lexical and grammatical arity-reduction: The case of reciprocity in Romance languages. [PDF]

Nat Lang Linguist Theory
Palmieri G, Basso R, Nieto I Bou J, Winter Y, Zwarts J.   +4 more
europepmc   +1 more source