Results 151 to 160 of about 564,000 (194)

Dense-Core Secretory Granule Biogenesis

Physiology, 2006
The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational ...
Taeyoon, Kim, Marjorie C, Gondré-Lewis, Irina, Arnaoutova, Y Peng, Loh   +3 more
openaire   +2 more sources

The role of Rab38 in platelet dense granule defects

Journal of Thrombosis and Haemostasis, 2008
The fawn-hooded hypertensive (FHH) rat has a mutation in the Rab38 gene that is associated with a platelet dense granule storage pool disease.To better characterize the expression and function of Rab38 in FHH rat and human megakaryocytes and platelets.Rab38 expression in FHH rat and normal tissues was demonstrated by western blotting.
I, Ninkovic, J G, White, A, Rangel-Filho, Y H, Datta   +3 more
openaire   +2 more sources

Platelet aggregation and dense granule secretion in schizophrenia

Psychiatry Research, 1994
The functional state of platelets and their possible impairment in response to various stimuli were assessed in saline-diluted citrated blood samples of normal male control subjects (n = 27), and in schizophrenic patients with (n = 34) and without (n = 23) haloperidol treatment.
J K, Yao, D P, van Kammen, J, Gurklis, J L, Peters   +3 more
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The Nature of Breast Dense Core Granules: Uranaffin Reactivity

Histopathology, 1987
In this study breast tissue that contained ultrastructural dense core granules has been examined from 24 patients. The possible neuroendocrine characteristics of the granules were studied using the uranaffin reaction and an ultrastructural argyrophil stain. The tissue included 15 breast carcinomas and nine benign samples. Two types of breast dense core
T J Anderson, T J Anderson
exaly   +3 more sources

Impaired Platelet-Dense Granule Release in Neonates

Journal of Pediatric Hematology/Oncology, 2000
The aim of this study is to examine differences in platelet dense granule (PDG) uptake and release between preterm infants, term infants, and adults.PDG uptake and release was examined by flow cytometry using mepacrine fluorescent staining in phycoerythrin-anti-GPIIb/IIIa bound platelets taken from cord blood of eight term infants and seven preterm ...
P, Mankin, J, Maragos, M, Akhand, K L, Saving   +3 more
openaire   +2 more sources

Dense Granule Factors

1997
“Platelet dense granule” is a descriptive name originating from the observation that these granules absorb electrons even in unfixed or lightly fixed, unstained mounts on electron microscopic examination. Their contents are also highly osmiophilic, with the result that they are the most electron-dense organelles after osmium staining.
openaire   +1 more source

Histamine In Pig Platelet Dense Granules

Thrombosis and Haemostasis, 1981
In the course of high resolution nuclear magnetic resonance (n.m.r.) studies of dense granule storage complexes, an amine with two aromatic protons was observed in a proton n.m.r. spectrum of dense granules isolated from pig platelets. This amine was identified as histamine by the exact coincidence of the n.m.r.
M H Fukami, K Ugurbil, H Holmsen, G L Pakstis, C A Dangelmaier   +4 more
openaire   +1 more source

The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion

Blood, 2005
Abstract Stimulation of platelets with strong agonists results in centralization of cytoplasmic organelles and secretion of granules. These observations have led to the supposition that cytoskeletal contraction facilitates granule release by promoting the interaction of granules with one another and with membranes of the open ...
Robert, Flaumenhaft, James R, Dilks, Nataliya, Rozenvayn, Rita A, Monahan-Earley, Dian, Feng, Ann M, Dvorak   +5 more
openaire   +2 more sources

Megakaryocyte dense granule components are sorted in multivesicular bodies

Blood, 2000
Recent studies suggest that multivesicular bodies are an intermediate stage in the formation of -granules. In contrast, the kinetics and mode of appearance of dense granules during megakaryocytic maturation has remained poorly understood. Immunoelectron microscopy was used to monitor the appearance of dense granular markers (granulophysin and ...
T, Youssefian, E M, Cramer
openaire   +2 more sources

On interchromatinic dense granules of mature human neutrophil granulocytes

Experimental Cell Research, 1971
Abstract Nuclear segments of human mature neutrophil granulocytes were investigated by light microscopic and ultrastructural cytochemical procedures to provide more information on the fine morphology and composition of interchromatinic dense granules in these cells.
K, Smetana, J, Lejnar, A, Vlastiborova, H, Busch   +3 more
openaire   +2 more sources