Neonatal Platelets: Lower G12/13 Expression Contributes to Reduced Secretion of Dense Granules [PDF]
Cells, 2022 Despite fully functional primary hemostasis, platelets of healthy neonates exhibit hypoaggregability and secretion defects, which may be adaptations to specific requirements in this developmental stage. The etiologies for reduced signal transduction vary
Axel Schlagenhauf +6 more
doaj +2 more sources
FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility [PDF]
eLifeRibonucleoprotein (RNP) granules are membraneless electron-dense structures rich in RNAs and proteins, and involved in various cellular processes. Two RNP granules in male germ cells, intermitochondrial cement and the chromatoid body (CB), are associated
Yuki Kaneda +7 more
doaj +2 more sources
Apical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma [PDF]
eLifeApicomplexans are ubiquitous intracellular parasites of animals. These parasites use a programmed sequence of secretory events to find, invade, and then re-engineer their host cells to enable parasite growth and proliferation.
Sara Chelaghma +5 more
doaj +2 more sources
A Morphometric Analysis of Platelet Dense Granules of Patients With Unexplained Bleeding: A New Entity of Delta-Microgranular Storage Pool Deficiency [PDF]
Journal of Clinical Medicine, 2020 Peter A Kouides +2 more
exaly +2 more sources
Decreased numbers of dense granules in fetal and neonatal platelets [PDF]
Haematologica, 2017 Denisa Urban +9 more
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Evaluation of human platelet granules by structured illumination laser fluorescence microscopy
Platelets, 2023 Many roles of human platelets in health and disease are linked to their ability to transport and secrete a variety of small molecules and proteins carried in dense (δ-) and α-granules.
Fred G. Pluthero, Walter H. A. Kahr
doaj +1 more source
Hermansky–Pudlak Syndrome Type 6 Accompanied with Bowel Vascular Malformation: Clinical Case
Вопросы современной педиатрии, 2021 Background. Hermansky–Pudlak syndrome type 6 is rare hereditary disease caused by pathogenic variants in base sequence, deletions, and insertions in the HPS6 gene encoding the transmembrane protein of the same name.
Natalia V. Zhurkova +9 more
doaj +1 more source
Transmission Electron Microscope Study of Melanocytes on the Mongolian Blue Spot Region
Central Asian Journal of Medical Sciences, 2020 Objectives: We aimed to study the melanocyte and melanin granules of the blue spot skin. Methods: The skin specimens were taken from the sacral region of a 1 and an 8 month old child and a 35 year old man.
Batchimeg Tsedendorj +4 more
doaj +1 more source
Folia Morphologica, 2022 BACKGROUND: The current study was designed to perform a transmission electron microscopic investigation focusing on the dark and light pancreatic acinar β-cells of young domesticated pig (Sus Suidae).
M. Elghoul +3 more
doaj +1 more source
The life cycle of platelet granules [version 1; referees: 2 approved]
F1000Research, 2018 Platelet granules are unique among secretory vesicles in both their content and their life cycle. Platelets contain three major granule types—dense granules, α-granules, and lysosomes—although other granule types have been reported.
Anish Sharda, Robert Flaumenhaft
doaj +1 more source