Results 11 to 20 of about 588,860 (289)

Requirements for the identification of dense-core granules

Trends in Cell Biology, 2004
Dense-core granules (DCGs), cytoplasmic organelles competent for regulated exocytosis, show considerable heterogeneity depending upon the specificity of their expressing cells--primarily neurons and neurosecretory cells. DCGs have been mainly identified by detecting their cargo molecules, often members of the granin family, and using conventional ...
Meldolesi J, Chieregatti E, Malosio ML
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Rab27b regulates number and secretion of platelet dense granules [PDF]

Proceedings of the National Academy of Sciences, 2007
The Rab27 GTPase subfamily consists of two closely related homologs, Rab27a and Rab27b. Rab27a has been shown previously to regulate organelle movement and regulated exocytosis in a wide variety of secretory cells. However, the role of the more restrictedly expressed Rab27b remains unclear. Here we describe the creation of
Tolmachova, T, Abrink, M, Futter, C E, Authi, K S, Seabra, M C   +4 more
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Calcium negatively regulates secretion from dense granules in Toxoplasma gondii. [PDF]

Cell Microbiol, 2019
Apicomplexan parasites including Toxoplasma gondii and Plasmodium spp. manufacture a complex arsenal of secreted proteins used to interact with and manipulate their host environment.
Katris NJ, Ke H, McFadden GI, van Dooren GG, Waller RF.   +4 more
europepmc   +5 more sources

Identification of Ca-rich dense granules in human platelets using scanning transmission X-ray microscopy. [PDF]

J Synchrotron Radiat, 2020
Whole-mount (WM) platelet preparation followed by transmission electron microscopy (TEM) observation is the standard method currently used to assess dense granule (DG) deficiency (DGD). However, due to the electron-density-based contrast mechanism in TEM,
Trinh TX, Kwon SJ, Gerelkhuu Z, Choi JS, Song J, Yoon TH.   +5 more
europepmc   +2 more sources

Human platelets contain a pool of free zinc in dense granules. [PDF]

Res Pract Thromb Haemost
Background: Activated platelets release procoagulant factors that include Ca2+ and Zn2+. Releasable Ca2+ stores have been identified in platelet dense granules and the dense tubular system, but similar stores of free Zn2+ have not been identified ...
Kahr WHA, Henderson SJ, Pluthero FG, Heijnen HFG, Vaezzadeh N, Stafford AR, Fredenburgh JC, Weitz JI.   +7 more
europepmc   +2 more sources

Sorting machineries: how platelet-dense granules differ from α-granules. [PDF]

Biosci Rep, 2018
Platelets respond to vascular injury via surface receptor stimulation and signaling events to trigger aggregation, procoagulant activation, and granule secretion during hemostasis, thrombosis, and vascular remodeling. Platelets contain three major types of secretory granules including dense granules (or δ-granules, DGs), α-granules (AGs), and lysosomes.
Chen Y, Yuan Y, Li W.
europepmc   +4 more sources

Organellar Proteomics of Human Platelet Dense Granules Reveals That 14-3-3ζ Is a Granule Protein Related to Atherosclerosis

, 2007
Dense granules, a type of platelet secretory organelle, are known to accumulate high concentrations of small molecules such as calcium, adenine nucleotides, serotonin, pyrophosphate, and polyphosphate.
Aurelio Serrano (8667681), Esther Ocaña (8667672), Laura Hernández-Ruiz (8667666), Ana Sáez-Benito (304974), Federico Valverde (3566096), Maria D. Jimenez-Nuñez (8667669), Felix A. Ruiz (8667684), Javier Rodríguez-Martorell (8667675), Juan-Carlos Bohórquez (8667678)   +8 more
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Transfer of a dense granule protein of Plasmodium falciparum to the membrane of ring stages and isolation of dense granules [PDF]

Infection and Immunity, 1992
A 14-kDa protein was localized to the dense granules of Plasmodium falciparum by immunoelectron microscopy with monoclonal antibody 1H1. The protein was present in dense granules in late-stage schizonts and free merozoites. After invasion, the protein was localized exclusively on the membrane of the newly invaded ring.
W, Trager, C, Rozario, H, Shio, J, Williams, M E, Perkins   +4 more
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Quantification of a novel dense granule protein (granulophysin) in platelets of patients with dense granule storage pool deficiency [PDF]

Blood, 1992
Abstract An antigen-capture sandwich enzyme-linked immunosorbent assay (ELISA) was developed for a novel protein granulophysin, a constituent of the platelet dense granule (DG) membrane and used to characterize patients with dense granule storage pool deficiency (delta-SPD).
A, Shalev, G, Michaud, S J, Israels, A, McNicol, S, Singhroy, E M, McMillan, J G, White, C J, Witkop, W L, Nichols, A H, Greenberg   +9 more
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PKD is for dense granule secretion [PDF]

Blood, 2011
Platelet secretion of dense granule contents is important for human hemostasis, as is evident from the mucocutaneous bleeding associated with disorders of dense granule biogenesis and secretion.1 Dense granule secretion is also important for growth and stability of platelet thrombi in experimental models of thrombosis.2 Although patients with primary ...
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