Results 251 to 260 of about 588,860 (289)
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Impaired Platelet-Dense Granule Release in Neonates
Journal of Pediatric Hematology/Oncology, 2000The aim of this study is to examine differences in platelet dense granule (PDG) uptake and release between preterm infants, term infants, and adults.PDG uptake and release was examined by flow cytometry using mepacrine fluorescent staining in phycoerythrin-anti-GPIIb/IIIa bound platelets taken from cord blood of eight term infants and seven preterm ...
P, Mankin +3 more
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1997
“Platelet dense granule” is a descriptive name originating from the observation that these granules absorb electrons even in unfixed or lightly fixed, unstained mounts on electron microscopic examination. Their contents are also highly osmiophilic, with the result that they are the most electron-dense organelles after osmium staining.
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“Platelet dense granule” is a descriptive name originating from the observation that these granules absorb electrons even in unfixed or lightly fixed, unstained mounts on electron microscopic examination. Their contents are also highly osmiophilic, with the result that they are the most electron-dense organelles after osmium staining.
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Histamine In Pig Platelet Dense Granules
Thrombosis and Haemostasis, 1981In the course of high resolution nuclear magnetic resonance (n.m.r.) studies of dense granule storage complexes, an amine with two aromatic protons was observed in a proton n.m.r. spectrum of dense granules isolated from pig platelets. This amine was identified as histamine by the exact coincidence of the n.m.r.
M H Fukami +4 more
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The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion
Blood, 2005Abstract Stimulation of platelets with strong agonists results in centralization of cytoplasmic organelles and secretion of granules. These observations have led to the supposition that cytoskeletal contraction facilitates granule release by promoting the interaction of granules with one another and with membranes of the open ...
Robert, Flaumenhaft +5 more
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Megakaryocyte dense granule components are sorted in multivesicular bodies
Blood, 2000Recent studies suggest that multivesicular bodies are an intermediate stage in the formation of -granules. In contrast, the kinetics and mode of appearance of dense granules during megakaryocytic maturation has remained poorly understood. Immunoelectron microscopy was used to monitor the appearance of dense granular markers (granulophysin and ...
T, Youssefian, E M, Cramer
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On interchromatinic dense granules of mature human neutrophil granulocytes
Experimental Cell Research, 1971Abstract Nuclear segments of human mature neutrophil granulocytes were investigated by light microscopic and ultrastructural cytochemical procedures to provide more information on the fine morphology and composition of interchromatinic dense granules in these cells.
K, Smetana +3 more
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Protein targeting to dense‐core secretory granules
BioEssays, 1993AbstractRegulated secretory proteins are stored within specialized vesicles known as secretory granules. It is not known how proteins are sorted into these organelles. Regulated proteins may possess targeting signals which interact with specific sorting receptors in the lumen of the trans‐Golgi network (TGN) prior to their aggregation to form the ...
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Platelet dense-granule centralization and the persistence of ADP secretion
American Journal of Physiology-Heart and Circulatory Physiology, 1996After activation of a human platelet, its adenosine diphosphate (ADP)-containing dense granules are moved toward the platelet's center and release their ADP into the channels of the open canalicular system (OCS). Mathematical modeling is used to investigate a possible role of this centralization in prolonging the duration of ADP secretion compared ...
A L, Fogelson, N T, Wang
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Dense Granule Antigens of Toxoplasma Gondii
1993In the search for protective antigens aiming at the development of a sub-unit vaccine against toxoplasmosis, several molecules have been found to represent good candidates, in particular P30 or SAG1, the major surface antigen of tachyzoite [Burg et al., 1988; Bulow and Boothroyd, 1991].
M-F. Cesbron-Delauw +4 more
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Dense granules (lysosomes?) and crystals in the thyroids of senile rats
American Journal of Anatomy, 1968AbstractWhile all follicular cells display some dense “lysosome‐like” granules (0.1–2.5 μ), they are more numerous and complex in animals of 14 months or older. There are various types of granules which share some morphological features, but vary in the extent to which they accumulate dense membranous fragments and droplets (0.02–0.4 μ) within their ...
J, Youson, H, van Heyningen
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