Results 51 to 60 of about 2,883,144 (286)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Dense and light core medium size vesicles.

, 2018
(A) Diameter distribution for dense and light core medium size vesicles. (B) Tomographic slices and corresponding radially averaged density traces (lower values indicate higher density) for a dense core with halo (top), a dense core without halo (middle)
Dimitri Vanhecke (84546), Ulrike Laugks (5334692), Nikolas Schrod (5334689), Miroslava Schaffer (5334686), Valentin Stein (334546), Wolfgang Baumeister (25915), Vladan Lucic (274390), Yoshiyuki Fukuda (5334695)   +7 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Multi step prediction of dense medium clean coal ash content based on time series alignment and TCNformer

Gong-kuang zidonghua
Due to the different positions of various sensors during the dense medium separation process, there is a time lag between the main process parameters of dense medium separation and ash content, which affects the results of clean coal ash content.
WANG Jun, WANG Ranfeng, WEI Kai, HAN Jie, ZHANG Qian   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The potential for dense medium separation of mineral fines using a laboratory Falcon Concentrator [PDF]

, 2017
Dense medium separation (DMS) is a technique used to separate particles based on specific gravity. Conventional DMS is, however, limited to coarse particle sizes and is not practical when processing fines.
Williams, H., Coelho, F., Waters, K. E., Rowson, N. A., Awais, M.; id_orcid, Kökkılıç, O., Marion, C., Langlois, R.   +7 more
core   +1 more source

Light shift of the Ramsey resonance of coherent population trapping in optically dense medium

, 2018
In this work we calculate the Ramsey resonances of coherent population trapping effect in cold atomic ensembles. The main goal is to investigate the light shift of the resonance on the different parameters in optically dense medium, because such medium ...
Popov Evgeniy, Voloshin Gavriil, Litvinov Andrey, Barantsev Konstantin, Gavriil Voloshin, Konstantin Barantsev, Andrey Litvinov, Evgeniy Popov   +7 more
core   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Heavy flavour $z_g$ in dense medium with late emission approximation

, 2023
We study the $z_g$ distribution for heavy flavour, i.e. bottom and charm quark, jets propagating through the dense QCD medium. We extend the late emission approximation for ASW formula to heavy flavours. % We consider both the normalised and $N_{\rm jet}$
Blok, Boris, Wu, Chang
core