Results 71 to 80 of about 904,708 (330)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Medium-scale 4-D ionospheric tomography using a dense GPS network [PDF]

Annales Geophysicae, 2013
The ionosphere above Scandinavia in December 2006 is successfully imaged by 4-dimensional tomography using the software package MIDAS from the University of Bath.
M. M. J. L. van de Kamp
doaj   +1 more source

Progenitors of Recombining Supernova Remnants

, 2012
Usual supernova remnants have either ionizing plasma or plasma in collisional ionization equilibrium, i.e., the ionization temperature is lower than or equal to the electron temperature.
Blinnikov, Chevalier, Dwarkadas, Dwarkadas, Fryer, Hachisu, Hachisu, Itoh, Kawasaki, Moriya, Neill, Ohnishi, Ozawa, Pakmor, Prieto, Sawada, Schlegel, Shimizu, Smith, Smith, Uno, Wellons, Yamaguchi   +22 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Study on influence of dense medium on impact pressure of detonation waves subjected to contact blasts

Xibei Gongye Daxue Xuebao
In order to investigate the buffering effect of the different dense medium on the shock waves in the contact blasts, a dimensional analysis method by using the zero-pressure sound speed of dense medium was proposed.
MENG Yuanpei, MA Yue, HE Yuan, GUO Lei, LING Qi, ZHOU Jie, WANG Chuanting, HE Yong   +7 more
doaj   +1 more source

Dense dislocations enable high-performance PbSe thermoelectric at low-medium temperatures

Nature Communications, 2022
Thermoelectric material is capable of realizing direct conversion between heat and electricity. Here, the authors obtain high thermoelectric performance in PbSe at low-medium temperatures by importing dense dislocations.
Liqing Xu, Yu Xiao, Sining Wang, Bo Cui, Di Wu, Xiangdong Ding, Li-Dong Zhao   +6 more
doaj   +1 more source

Holographic Meson Spectra in the Dense Medium with Chiral Condensate

, 2011
We study two $1/N_c$ effects on the meson spectra by using the AdS/CFT correspondence where the $1/N_c$ corrections from the chiral condensate and the quark density are controlled by the gravitational backreaction of the massive scalar field and U(1 ...
Bum-Hoon Lee, Chanyong Park, E. Witten, E. Witten, E. G. Drukarev, E. G. Drukarev, J. M. Maldacena, Sunyoung Shin   +7 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Neutrino photoproduction on pseudo Nambu-Goldstone bosons

, 2013
Production of single neutrinos as well as neutrino-antineutrino pairs by photons interacting with pseudo Nambu-Goldstone bosons is studied within the Standard Model. The corresponding cross sections are found analytically. The energy loss due to neutrino
Adler, Alikhanov, Arretche, Bahcall, Bardeen, Bell, Beringer, Blaschke, Bryman, Caldas, Chen, Chen, Gershtein, Goldstone, Goldstone, Harvey, Hashimoto, I. Alikhanov, Jaikumar, Kajantie, Klevansky, Komachenko, Loewe, Maxwell, Mota, Muller, Nambu, Nambu, Nambu, Natale, Nussinov, Petrukhin, Raffelt, Reddy, Shuryak, Shuryak, Umeda, Vaks   +37 more
core   +1 more source