Results 61 to 70 of about 121,711 (277)

Improving the Distribution of Densities in Southern California  [PDF]

open access: yes, 2020
Many of the biggest transportation challenges in Southern California arise not due to its overall density but due to the lack of concentration of densities.
Kim, Jae Hong, Li, Xiangyu
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Pouvoir des séries télévisées

open access: yesCommunication, 2014
The author questions the notion of power as it relates to TV series. He rejects the concept of the all-powerful, deceiving cultural industry. The kind of power a TV series may exert lies in its ability to maintain its viewers in a state of fictional ...
Jean-Pierre Esquenazi
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Technical Rate of Substitution of Spectrum in Future Mobile Broadband Provisioning

open access: yes, 2015
Dense deployment of base stations (BSs) and multi-antenna techniques are considered key enablers for future mobile networks. Meanwhile, spectrum sharing techniques and utilization of higher frequency bands make more bandwidth available.
Sung, Ki Won, Yang, Yanpeng
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Dense Pure Tungsten Fabricated by Selective Laser Melting

open access: yesApplied Sciences, 2017
Additive manufacturing using tungsten, a brittle material, is difficult because of its high melting point, thermal conductivity, and oxidation tendency.
Dianzheng Wang   +5 more
doaj   +1 more source

Evaluation of Kalalani vermiculite for production of high strength porcelain insulators [PDF]

open access: yesScience of Sintering, 2019
The present work has evaluated Kalalani vermiculite as a potential raw material for the production of high strength porcelain insulators. Three porcelain compositions were prepared to contain 0, 20 and 30 wt% of Kalalani vermiculite.
Ngayakamo Blasius, Park Eugene S.
doaj   +1 more source

Full-Densification of SLS Parts by Re-Melting [PDF]

open access: yes, 2004
Among commercially available rapid prototyping processes, SLS is the most effective in terms of adaptability of various materials. However, rapid prototyped parts by the process are always porous and the physical properties of the parts are different ...
Niino, T., Yamada, H.
core   +1 more source

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