Results 61 to 70 of about 50,134 (248)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Densification and Mechanical Properties of ZrN-Nb Composites

Journal of Aeronautical Materials, 2018
Densification of zirconium nitride (ZrN) ceramics was investigated by vacuum hot pressing at temperatures range from 1500℃to 2000℃with Nb as sintering additive. Densification was enhanced with Nb addition.
ZHANG Yan, GUO Yingkui
doaj   +1 more source

Densification of activated sludge for better settling performances: experimental characterization in batch column and model parameters calibration

Water Science and Technology, 2022
Conventional activated sludge (CAS) and densified sludge obtained using hydro-cyclone selective wasting were compared at a full-scale water resources recovery facility.
Clément Roche, Maria Elena Valle Medina, Philippe Schmitt, Anne Pallarès, Gwenaël Pallarès, Mélanie Meilliez, Julien Laurent   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effect Of Ti Powder Addition On The Fabrication Of TiO2 Nanopowders

Archives of Metallurgy and Materials, 2015
Sintered samples of Ti added TiO2 nanopowders were fabricated by combined application of magnetic pulsed compaction (MPC) and sintering. The effect of Ti nano powder on density, shrinkage and hardness of the samples were investigated as part of the study.
Raihanuzzaman R.M., Park H.Y., Ghomashchi R., Kwon T.H., Son H.-T., Hong S.J.   +5 more
doaj   +1 more source

Investigation of Decarburization Behaviour during the Sintering of Metal Injection Moulded 420 Stainless Steel

Metals, 2020
The decarburization behaviour during the sintering of metal-injection-moulded 420 stainless steel was investigated. Particular attention has been paid to the decarburization mechanisms and carbon distribution of parts sintered at different temperatures ...
Jia Lou, Muyao Liu, Hao He, Xinming Wang, Yimin Li, Xiaoping Ouyang, Chuanfeng An   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Densification of wood

, 2007
Članek obravnava procese, ki potekajo med postopkom zgoščevanja lesa, in podaja pregled dosežkov relevantnih raziskav, v katerih je bilo proučevano zgoščevanje lesa s kombiniranim postopkom hidrotermične obdelave in stiskanja.Predstavljena je viskoelastična narava lesa, skupaj s toplotnim mehčanjem oziroma plastifikacijo.
Kutnar, Andreja, Šernek, Milan
openaire   +5 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source