Results 111 to 120 of about 84,432 (239)

Single‐Cell Fluorescence Imaging Reveals Heterogeneity in Senescence Biomarkers and Identifies Rapamycin‐Responsive Sub‐Populations

open access: yesAging Cell, EarlyView.
Cellular senescence induced by distinct stressors generated heterogeneous populations with variable expression of canonical biomarkers. Rapamycin showed selective senomorphic effects on specific subpopulations, while the senolytic agent ABT‐263 effectively eliminated all senescent cells, regardless of biomarker heterogeneity.
Vijayraghavan Seshadri   +8 more
wiley   +1 more source

Dietary Citrate Restores Age‐Related Endothelial Cell Mitochondrial Dysfunction and Alleviates Atherosclerosis

open access: yesAging Cell, EarlyView.
Citrate, as a common food additive, provides the major cellular ATP source. This study demonstrates that dietary citrate attenuates common vascular diseases, including atherosclerosis and hypertension, and reduces frailty in mice by delaying vascular aging.
Ya Zhao   +11 more
wiley   +1 more source

Peri‐ and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice

open access: yesAging Cell, EarlyView.
Postnatal high fat (HF) feeding negatively impacts executive function in both adult and aged mice, but consumption of the same diet during the perinatal period only is beneficial in older age. Maternal HF diet is associated with increased cholinergic innervation of the prefrontal cortex of young, but not aged, offspring.
Laura Contu   +3 more
wiley   +1 more source

Fish Allergenicity Ladder and Parvalbumin Epitopes for Predicting Clinical Cross‐Reactivity and Reintroduction in Chinese Population

open access: yesAllergy, EarlyView.
Clinical history including self‐reported history and oral food challenge outcome, and sIgE sensitization profile of 200 subjects with suspected fish allergy was analyzed to construct a 3‐step fish allergenicity ladder. The allergenicity ladder was positively linked to the relative parvalbumin content of fish muscle but not to differences in the IgE ...
Christine Y. Y. Wai   +21 more
wiley   +1 more source

A randomised controlled trial on cross‐linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To present the outcomes of a randomised clinical trial for the treatment of progressive keratoconus using different kinds of riboflavin and the addition of sterile water in thin corneae. Methods A randomised study using epithelium‐off corneal cross‐linking (CXL) with continuous UVA irradiance 9 mW/cm2 for 10 min (total fluence 5.4 J ...
Ingemar Gustafsson   +5 more
wiley   +1 more source

Urinary Calcium and Phosphorus Excretion in Vitamin D‐Sufficient Preterm Infants: Establishing Age‐Specific Normative Data

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim This study evaluated urinary calcium (Ca) and phosphorus (P) excretion in very low birth weight infants ( < 1500 g, VLBW) without severe morbidity, treated with methylxanthines. Methods Eighty‐one VLBW infants were analysed. Urinary Ca and P and their creatinine ratios were measured biweekly until day 56.
Tomas Matejek   +5 more
wiley   +1 more source

Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Activation of Protein Phosphatase 2A (PP2A), via genetic and pharmacologic modulation of SET, has recently being identified as a promising strategy to therapeutically target acute myeloid leukaemia (AML) carrying KMT2A (MLL) chromosomal translocations (KMT2A‐r AML).
Yoana Arroyo‐Berdugo   +11 more
wiley   +1 more source

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