Results 111 to 120 of about 248,416 (349)

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Cooperation of Gq, Gi, and G12/13 in Protein Kinase D Activation and Phosphorylation Induced by Lysophosphatidic Acid [PDF]

, 2003
To examine the contribution of different G-protein pathways to lysophosphatidic acid (LPA)-induced protein kinase D (PKD) activation, we tested the effect of LPA on PKD activity in murine embryonic cell lines deficient in Galpha q/11 (Galpha q/11 KO ...
Gu, Jennifer, Rozengurt, Enrique, Slice, Lee W., Yuan, Jingzhen   +3 more
core  

Role of arginase 2 in systemic metabolic activity and adipose tissue fatty acid metabolism in diet-induced obese mice [PDF]

, 2019
Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase enzyme with two isoforms (A1-cytosolic and A2-mitochondrial), is implicated in ...
Atawia, Reem T, Benson, Tyler W, Caldwell, Robert W, Caldwell, Ruth B, Cutler, Christopher W, Meghil, Mohamed M, Toque, Haroldo A, Weintraub, Neal L, Yiew, Nicole K.H   +8 more
core   +2 more sources

New algorithm for corneal densitometry assessment based on anterior segment optical coherence tomography

Eye, 2021
X. Wang, Tianqiao Zhang, Anil Rahul Rachwani, I. Blanco-Domínguez, C. Rocha de Lossada, Afredo Manuel Adán-Civiera, J. Peraza-Nieves   +6 more
semanticscholar   +1 more source

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

The Potential of a Laser-Aspiration Solution for Refractive Lens Exchange

Oftalʹmologiâ
Introduction. This review presents the current knowledge about the methods of lens surgery for the correction of refractive errors in patients with presbyopia and other refractive errors. And also about possible methods of minimization of ultrasound load
D. E. Arakelyan, S. Yu. Kopaev, I. A. Il’inskaya, V. V. Pominova   +3 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Application of X-ray technique in nondestructive evaluation of eucalypt wood

Maderas: Ciencia y Tecnología, 2014
X-rays were initially used for the inspection of special-purpose wood pieces for quantitative evaluation of wood properties of different species. X-ray densitometry has had its use expanded in dendroclimatology of Picea engelmannii trees.
M. Tomazello, S. Brazolin, M. P. Chagas, J. T. S. Oliveira, A. W. Ballarin, C. A. Benjamin   +5 more
doaj  

Interstitial Lung Disease Outcome Prediction Using Quantitative Densitometry Indices on Baseline Chest Computed Tomography

Diagnostics
Background/Objectives: Accurate prognostication for interstitial lung disease (ILD) remains challenging, limiting clinicians’ ability to optimize patient management strategies. This study aimed to evaluate the prognostic value of baseline quantitative CT-
Li-Ting Huang, Tang-Hsiu Huang, Chung-Ying Lin, Hao Ho, Yi-Shan Tsai, Chia-Ying Lin, Chien-Kuo Wang   +6 more
doaj   +1 more source