Results 181 to 190 of about 252,175 (379)

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

open access: yesInterdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui   +12 more
wiley   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

open access: yesInterdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen   +12 more
wiley   +1 more source

Kaempferitrin's Dual Assault: Inducing Apoptosis and Ferroptosis in Diffuse Large B‐Cell Lymphoma via NF‐κB Inactivation

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common non‐Hodgkin lymphoma and is an aggressive and highly heterogeneous tumor. Kaempferitrin (KPF) is a natural flavonoid glycoside that exerts a protective role in multiple human tumors. However, the impact of KPF on DLBCL remains unclear.
Han‐Shuo Zhang   +3 more
wiley   +1 more source

Factores de riesgo asociados a la enfermedad osteoporótica en una población femenina postmenopáusica

open access: yesRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2019
Fundamento: la osteoporosis posmenopáusica se caracteriza por una pérdida acelerada y desproporcionada de hueso trabecular. Se ha convertido en un grave problema de salud, nacional e internacionalmente, debido a la alta incidencia de fracturas.Objetivo ...
Alfredo Enrique Arredondo-Bruce   +1 more
doaj  

Findings in human lenses 40 years after injection of Ra-224 [PDF]

open access: yes, 1994
Egner, P.   +7 more
core   +1 more source

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