Results 191 to 200 of about 84,432 (239)

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice

Biotechnology and Bioengineering, Volume 122, Issue 10, Page 2709-2723, October 2025.
ABSTRACT Plasma transferrin (Tf) is the transport protein central to the process of iron recycling and metabolism. Holo‐Tf serves as the body's pool of ferric iron, facilitating transport from tissues such as the intestine, liver, spleen, and finally bone marrow, where iron is incorporated into erythropoiesis.
Shuwei Lu, Mohd A. Khan, Saini Setua, Quintin O'Boyle, Kiruphagaran Thangaraju, Pedro Cabrales, Delaney C. Swindle, David C. Irwin, Paul W. Buehler, Andre F. Palmer   +9 more
wiley   +1 more source

The Effect of Cachexia on the Feeding Regulation of Skeletal Muscle Protein Synthesis in Tumour‐Bearing Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Cancer promotes muscle wasting through an imbalance in the tightly regulated protein synthesis and degradation processes. An array of intracellular signalling pathways, including mTORC1 and AMPK, regulate protein synthesis, and these pathways are responsive to the muscle's microenvironment and systemic stimuli.
Brittany R. Counts, Quan Zhang, Jessica L. Halle, Melissa J. Puppa, Stephen E. Alway, Junaith Mohamed, Jeremy P. Loenneke, James A. Carson   +7 more
wiley   +1 more source

Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions

The Journal of Pathology, Volume 267, Issue 2, Page 181-195, October 2025.
Abstract High‐risk neuroblastomas exhibit a high degree of intratumoral heterogeneity. Single‐cell RNA sequencing has greatly improved our understanding of these tumors, but the method lacks cellular tissue context and spatial information about local signaling dynamics.
Joachim T Siaw, Peter Merseburger, Marcus Borenäs, Caroline Jansson, Jenny Karlsson, Arne Claeys, Eva Jennische, Dan E Lind, David Gisselsson Nord, Ruth H Palmer, Jimmy Van den Eynden   +10 more
wiley   +1 more source

Hydrophobic residues in the D‐domain of a plasminogen‐binding M‐protein modulate α‐helicity, oligomerization, and surface anchoring in Streptococcus pyogenes

Protein Science, Volume 34, Issue 10, October 2025.
Abstract Human plasminogen (hPg) binding M‐protein (PAM) is a major virulence determinant of Group A Streptococcus (GAS). PAM contains irregularly spaced heptad repeats, particularly within its C‐ and D‐domains. Our recent cryo‐EM structure of PAM from GAS strain AP53 (PAMAP53) revealed that these repeats do not favor coiled‐coil formation, but instead
Olawole Ayinuola, Yetunde A. Ayinuola, Zhong Liang, Francis J. Castellino   +3 more
wiley   +1 more source

Rational design of a covalent ACE2 decoy receptor that broadly neutralizes SARS‐CoV‐2 variants

Protein Science, Volume 34, Issue 10, October 2025.
Abstract The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and the emergence of variants that evade existing vaccines and antibody therapies necessitate novel, potent, and broad‐spectrum antiviral strategies. Enhancing therapeutic proteins with additional covalent binding capabilities, such as minibinders and ...
Nobumasa Hino, Risa Takada, Kyosuke Suzuki, Nagisa Tokunoh, Tatsuya Karaki, Kazumasa Ohtake, Haruna Ogami, Takafumi Nishiura, Kenji Ishimoto, Tomohito Tsukamoto, Yukio Ago, Yoshiaki Okada, Toru Okamoto, Chikako Ono, Yoshiharu Matsuura, Satoshi Obika, Kensaku Sakamoto, Yasuo Yoshioka, Shinsaku Nakagawa   +18 more
wiley   +1 more source

Pleural Effusion Formation Linked to Altered Transporter Expression Involved in Alveolar Fluid Clearance: Insights From the Monocrotaline Model of Pulmonary Hypertension

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.
ABSTRACT Pleural effusions (PLEF) in pulmonary arterial hypertension (PAH), particularly in patients with isolated right heart failure, are associated with poor prognosis and increased mortality. This study investigates changes in alveolar fluid clearance (AFC) transporter expression in relation to lung fluid accumulation and PLEF formation during PAH ...
Katarina Lelkova, Katarina Hadova, Michaela Katanova, Jana Babiakova, Zuzana Albert Kmecova, Emil Babiak, Pavel Babal, Gabriel Doka, Jan Klimas, Peter Krenek   +9 more
wiley   +1 more source

Additive Effects of Multiple Photoprotective Mechanisms Drive Efficient Photosynthesis Under Variable Light Conditions

Plant, Cell &Environment, Volume 48, Issue 10, Page 7186-7198, October 2025.
ABSTRACT To cope with changing external conditions, plants undergo dynamic acclimation processes that adjust their photosynthetic machinery, optimising energy use while minimising damage to photosystems (PS). Key photoprotective mechanisms include non‐photochemical quenching (NPQ), which dissipates excess excitation energy, and alternative electron ...
Claudia Beraldo, Chiara Toffanin, Tomas Morosinotto, Alessandro Alboresi   +3 more
wiley   +1 more source

CD8+ T‐Cell Deletion Suppressed the Development of Injury‐Induced Experimental Neointimal Hyperplasia in Mice With or Without Chronic Stress

The FASEB Journal, Volume 39, Issue 18, 30 September 2025.
Graphical illustration of the mechanism of vascular remodeling under chronic stress. CD8+ T‐cell functions as an important mediator of injury‐related experimental neointimal hyperplasia via the modulation of inflammation, proteolysis and proliferation that is mediated by the IFN‐γ/AT1R‐galactin‐3 and mTOR/Akt‐p38MAPK axes.
Jingyuan Jin, Meiling Piao, Xianji Piao, Shangzhi Shu, Longguo Zhao, Zhibo Wang, Xueling Yue, Jinshun Piao, Xianglan Jin, Lina Hu, Yongshan Nan, Xian Wu Cheng   +11 more
wiley   +1 more source

Unsaturated Phosphine Oxides for Modular Antibody Rebridging and Single Reagent Peptide‐Cyclization‐Bioconjugation

Angewandte Chemie International Edition, Volume 64, Issue 38, September 15, 2025.
We report the modular synthesis of unsaturated P5 reagents starting from triethynyl‐phosphine oxide via CuAAC. Diethynyl‐triazolyl‐phosphine oxides enable rapid, selective and stable antibody disulfide rebridging, exemplified by the generation of a potent and selective ADC. In addition, triethynyl‐phosphine oxide enables a unique single reagent peptide‐
Christian E. Stieger, Alastair J. McMillan, Mark A. R. de Geus, Jan Vincent V. Arafiles, Luise Franz, Christian P. R. Hackenberger   +5 more
wiley   +1 more source

Partial Deletion of the Carboxyl‐Terminal Signal Sequence of the Cellular Prion Protein Alters Protein Expression via Endoplasmic Reticulum–Associated Degradation

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Knock‐in mice expressing PrP with a partial deletion of the C‐terminal signal sequence (KIBVPrP248) showed reduced PrPC expression and resistance to prion infection. The underlying mechanism is that the mutant PrP is aberrantly retained in the endoplasmic reticulum and eventually undergoes proteasomal degradation.
Miryeong Yoo, Sungeun Lee, Jieun Kim, Sunyeong Cha, Min Young Lee, Yeon Jeong Hwang, Woo‐Ri Ko, Taeeun Kim, A‐ran Kim, Trang H. T. Trinh, Young‐Mi Kim, Yong‐Pil Cheon, Chongsuk Ryou   +12 more
wiley   +1 more source