Results 231 to 240 of about 149,082 (291)

Cardiovascular Safety of VIAN‐c4551, an Antiangiogenic Peptide Derived From Vasoinhibin

Drug Development Research, Volume 86, Issue 7, November 2025.
ABSTRACT Vasoinhibin is a potent antiangiogenic protein that blocks the activation of endothelial nitric oxide synthase (eNOS) in response to vascular endothelial growth factor, bradykinin, and acetylcholine (ACh). In this regard, VIAN‐c4551, a new synthetic vasoinhibin analog, has therapeutic potential for targeting angiogenesis in oncology and ...
Miguel A. García‐González, Alejandro D. Miguel‐Martínez, Abimael González‐Hernández, Magdalena Zamora, Elva Adán‐Castro, Xarubet Ruíz‐Herrera, María A. Carbajo‐Mata, Jakob Triebel, Thomas Bertsch, José G. Lopez‐Lopez, Gonzalo Martínez de la Escalera, Juan Pablo Robles, Carmen Clapp, Carlos M. Villalón   +13 more
wiley   +1 more source

Integrating deep learning for post-translational modifications crosstalk on Hsp90 and drug binding. [PDF]

J Biol Chem
Heritz JA, Meluni KA, Backe SJ, Cayaban SJ, Wengert LA, Kunz M, Woodford MR, Bourboulia D, Mollapour M.   +8 more
europepmc   +1 more source

Combining Network Pharmacology, Molecular Docking, and Integrative Studies to Explore the Mechanism of Helminthostachys zeylanica in Alleviating Ulcerative Colitis

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
The experiment verified the mechanism of HZ against ulcerative colitis. Verified through in vivo and in vitro experiments, HZ demonstrated partial inhibition of the TLR4/NF‐κB signaling pathway, reduction in inflammatory factors IL‐6 and TNF, and the ability to suppress T cell differentiation and activation in ulcerative colitis.
Chih‐Ting Lin, Li‐Wei Lin, Li‐Ching Chang, Lung‐Yuan Wu, Fan‐Shiu Tsai   +4 more
wiley   +1 more source

GPR81 nuclear transportation is critical for cancer growth and progression in lung and other solid cancers. [PDF]

World J Clin Oncol
Yang L, Kono T, Gilbertsen A, Li Y, Sun B, Jacobson BA, Karam S, Dehm SM, Henke CA, Kratzke RA.   +9 more
europepmc   +1 more source

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing

Glia, Volume 73, Issue 11, Page 2253-2272, November 2025.
Main Points Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production.
Sarah Geller, Nadège Zanou, Sylviane Lagarrigue, Tamara Zehnder, Cathy Gouelle, Tania Santoro, Cendrine Repond, Paola Bezzi, Francesca Amati, Anne‐Karine Bouzier‐Sore, Ariane Sharif, Luc Pellerin   +11 more
wiley   +1 more source

Bone Mineral Accrual From Adolescence Into Young Adulthood and Peak Bone Mass: A Longitudinal Cohort Study

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Aims Understanding bone mass accumulation patterns and factors influencing them during growth is important for preventing osteoporosis later in life. This study investigated longitudinal changes in bone mineral content (BMC), bone mineral density (BMD), and bone mineral apparent density (BMAD) during growth, with the aim of ...
Arzhang Naseri, Farnaz Atighi, Alireza Keshtkar, Pedram Talezadeh, Marzieh Bakhshayeshkaram, Marjan Jeddi, Mohammad Mahdi Dabbaghmanesh, Seyed Taghi Heydari, Naeimehossadat Asmarian, Mohammad Hossein Dabbaghmanesh   +9 more
wiley   +1 more source

The use of regenerative technologies for treatment of delayed fracture union in patient with menopausal osteoporosis. [PDF]

Prz Menopauzalny
Maslennikov S, Kozhemyaka M, Golovakha M.   +2 more
europepmc   +1 more source

Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling

MedComm, Volume 6, Issue 11, November 2025.
Proposed model of the interaction of the H3K18la lactylation with GATA4 to promote the cardiac hypertrophy. The image was created using Home for Researchers.com. ABSTRACT Histone lactylation, particularly histone H3 lysine 18 lactylation (H3K18la), modulates gene expression profile in diverse cellular processes, which has emerged as a critical factor ...
Mingzhu Wang, Zixian Liu, Yongbo Ma, Da Li, Yuan Lin, Yani Wang, Deyu Fu, Haidong Guo, Liang Hu   +8 more
wiley   +1 more source

Lysosomal LRRC8 complex impacts lysosomal pH, morphology, and systemic glucose metabolism. [PDF]

Sci Adv
Kumar A, Zhao Y, Xie L, Chadda R, Tranter JD, Mikami RT, Abraham N, Hong J, Feng E, Rawnsley DR, Liu H, Henry KM, Meyer G, Hu M, Xu H, Hinton A, Grueter CE, Abel ED, Norris AW, Diwan A, Sah R.   +20 more
europepmc   +1 more source

Comparative Analysis of Corneal Morphological and Optical Parameters in Predicting DSAEK Surgery Outcome. [PDF]

Medicina (Kaunas)
Geber A, Masnec S, Kalauz M, Bešlić I, Škegro I, Gaćina DL, Jandroković S, Meter A, Kuzman T.   +8 more
europepmc   +1 more source