Results 251 to 260 of about 248,416 (349)

Scratching beneath the surface: Quantification of muscle architecture and myosin heavy chain content in the forelimbs of black‐tailed prairie dogs (Cynomys, Rodentia)

open access: yesJournal of Anatomy, EarlyView.
Black‐tailed prairie dogs are highly social ground squirrels that excavate communal burrow systems, most often in medium‐textured soils. Their forelimbs demonstrate morphofunctional trade‐offs for scratch‐digging and terrestrial ecology, including well‐developed and fast‐contracting proximal musculature with large mechanical advantage paired with ...
Luke A. Scheetz   +4 more
wiley   +1 more source

Typhoid Toxin of Salmonella enterica Induces ISG15 Responses Mediating Host Cell Survival and Counteracting Intracellular Infection

open access: yesMolecular Microbiology, EarlyView.
Toxigenic Salmonella enterica exocytose the typhoid toxin during infection causing host cell DNA damage, which activates a Type‐1 Interferon‐like response characterised by interferon‐stimulated gene 15 (ISG15) expression. ISG15 was required for host cell survival during Interferon responses and suppressed intracellular growth of Salmonella. Thus, ISG15
Daniel S. Stark   +11 more
wiley   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

open access: yesNeurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao   +6 more
wiley   +1 more source

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

open access: yesMolecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai   +7 more
wiley   +1 more source

Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer. [PDF]

open access: yesCancer Res
Herzog SK   +18 more
europepmc   +1 more source

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