Results 231 to 240 of about 248,416 (349)

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Probing the activity of cysteine cathepsins in inflammatory bowel diseases. [PDF]

Sci Rep
Anderson BM, Ziegler AR, Campden RI, Wu H, Xu B, McQuade RM, Carbone SE, Poole DP, Lomax AE, Reed DE, Vanner SJ, Yates RM, Bunnett NW, Edgington-Mitchell LE.   +13 more
europepmc   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Inducing TRIB2-targeted protein degradation to reverse chemoresistance in acute myeloid leukaemia. [PDF]

Biochem J
Rigby E, Fasanella Masci F, Narayanan A, Kania E, Harris JA, Williams J, Zhang B, Liu L, Richmond L, Zhou F, Ding K, Carmody RJ, Eyers PA, Keeshan K.   +13 more
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages. [PDF]

ASN Neuro
Jeffries MA, Putatunda R, Cruz-Berríos M, Romer MA, Singhal A, Jordan-Sciutto KL, Grinspan JB.   +6 more
europepmc   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Higher-Order Aberrations, Corneal Density, and Visual Acuity After Excimer Laser Phototherapeutic Keratectomy (PTK) for Epithelial Basement Membrane Dystrophy. [PDF]

J Ophthalmol
Helm S, Wiedemann J, Rosswinkel B, Bachmann B, Cursiefen C, Schlereth S.   +5 more
europepmc   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathy. [PDF]

Nat Cardiovasc Res
Lu YW, Liang Z, Dorr K, Ruiz S, Huang X, Fangnibo Hanvi D, Juntilla SM, Beutner G, Lyu S, Guo H, Fernandes T, Espinoza-Lewis RA, Wang T, Li K, Li X, Bir Singh G, Wang Y, Deng R, Cowan D, Mably JD, Pu WT, Huang J, Porter GA, Conlon F, Chen H, Wang DZ.   +25 more
europepmc   +1 more source