Results 41 to 50 of about 1,722,167 (288)

Integrating telemetry data at several scales with spatial capture–recapture to improve density estimates

open access: yesEcosphere, 2021
Accurate population estimates are essential for monitoring and managing wildlife populations. Mark–recapture sampling methods have regularly been used to estimate population parameters for rare and cryptic species, including the federally listed Mojave ...
Corey I. Mitchell   +7 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa   +3 more
wiley   +1 more source

Deep Generative Models to Counter Class Imbalance: A Model-Metric Mapping With Proportion Calibration Methodology

open access: yesIEEE Access, 2021
The most pervasive segment of techniques in managing class imbalance in machine learning are re-sampling-based methods. The emergence of deep generative models for augmenting the size of the under-represented class, prompts one to review the question of ...
Behroz Mirza   +4 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Interpretability With Accurate Small Models

open access: yesFrontiers in Artificial Intelligence, 2020
Models often need to be constrained to a certain size for them to be considered interpretable. For example, a decision tree of depth 5 is much easier to understand than one of depth 50. Limiting model size, however, often reduces accuracy.
Abhishek Ghose, Balaraman Ravindran
doaj   +1 more source

Parallel Space-Time Kernel Density Estimation

open access: yes, 2017
The exponential growth of available data has increased the need for interactive exploratory analysis. Dataset can no longer be understood through manual crawling and simple statistics.
Delmelle, Eric   +4 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Forest Density Estimation [PDF]

open access: yes, 2010
We study graph estimation and density estimation in high dimensions, using a family of density estimators based on forest structured undirected graphical models.
Gu, Haijie   +5 more
core   +1 more source

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