Results 61 to 70 of about 392,201 (264)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Cascaded Multi-Task Learning of Head Segmentation and Density Regression for RGBD Crowd Counting
IEEE Access, 2020 In this paper we propose a novel regression based RGBD crowd counting method. Compared with previous RGBD crowd counting methods which mainly exploit depth cue to facilitate person/head detection, our approach adopts density map regression and is more ...
Desen Zhou, Qian He
doaj +1 more source
The Density of the Maximum Likelihood Estimator
Econometrica, 1999 In this paper we derive an expression for the exact density of the maximum likelihood estimator (MLE) in the case where the MLE is uniquely defined at each point in the sample space by the vanishing of the score vector.
Hillier, G, Armstrong, M
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Estimating the Density of the Abundant Numbers
Integers, 2019 See the abstract in the attached pdf.
Klyve, Dominic +2 more
openaire +4 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
A comparison of density estimation methods for monitoring marked and unmarked animal populations
Ecosphere, 2022 Effective monitoring of wildlife populations forms the foundation of modern‐day conservation biology. Without reliable estimates of population size, it is not possible to determine population trends, a key requirement in determining species status under ...
Joshua P. Twining +8 more
doaj +1 more source
Estimation of Probability Density
The Annals of Mathematical Statistics, 1965 Assuming that the distribution being sampled is absolutely continous, Parzen [3] has established the consistency and asymptotic normality of a class of estimators $\{f_n(x)\}$ based on a random sample of size $n$, for estimating the probability density.
openaire +2 more sources