Results 81 to 90 of about 392,201 (264)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Densities for Ternary System of CaCl2–H2O–CO2 at Elevated P-T: An Experimental and Modeling Approach

open access: yesEnergies, 2018
Very few thermodynamic models exist for estimation of density alteration due to solution of CO2 in a pure H2O and CaCl2–H2O system. All of these models require density of CaCl2 solution to estimate density of CaCl2–H2O–CO2 system ...
Alireza Bastami   +2 more
doaj   +1 more source

Real‐Time Thermospheric Density Estimation via Two‐Line Element Data Assimilation

open access: yesSpace Weather, 2020
Inaccurate estimates of the thermospheric density are a major source of error in low Earth orbit prediction. Therefore, real‐time density estimation is required to improve orbit prediction.
David J. Gondelach, Richard Linares
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The benchden Package: Benchmark Densities for Nonparametric Density Estimation

open access: yesJournal of Statistical Software, 2012
This article describes the benchden package which implements a set of 28 example densities for nonparametric density estimation in R. In addition to the usual functions that evaluate the density, distribution and quantile functions or generate random ...
Thoralf Mildenberger, Henrike Weinert
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Phytoplankton Sampling: When the Method Shapes the Message

open access: yesLimnological Review
Different sampling techniques were evaluated to assess potential differences in species richness and the abundances of phytoplankton across several lowland aquatic environments.
Diego Frau
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Semi-Supervised Density Estimation with Background-Augmented Data for In Situ Seed Counting

open access: yesAgriculture
Direct seeding has gained prominence as a labor-efficient and environmentally sustainable alternative to conventional transplanting in rice cultivation. In direct seeding systems, early-stage management is crucial for stable seedling establishment, with ...
Baek-Gyeom Sung   +4 more
doaj   +1 more source

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