Results 81 to 90 of about 4,404,911 (264)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Does Anonymity Matter in Electronic Limit Order Markets? [PDF]

, 2004
Lecture on the first SFB/TR 15 meeting, Gummersbach, July, 18 - 20, 2004We develop a model of limit order trading in which some traders have better information on future price volatility.
Foucault, Thierry, Theissen, Erik, Moinas, Sophie   +2 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Low-density parity-check codes and their rateless relatives

, 2011
This survey guides the reader through the extensive open literature that is covering the family of low-density parity-check LDPC codes and their rateless relatives.
Sheng Chen, Chen, Sheng, Nicholas Bonello, Bonello, Nicholas, Hanzo, Lajos, Lajos Hanzo   +5 more
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

logcondens: Computations Related to Univariate Log-Concave Density Estimation [PDF]

Maximum likelihood estimation of a log-concave density has attracted considerable attention over the last few years. Several algorithms have been proposed to estimate such a density. Two of those algorithms, an iterative convex minorant and an active set
Lutz Dümbgen, Kaspar Rufibach
core  

One-dimensional QCD at finite density and its ’t Hooft-Veneziano limit

Journal of High Energy Physics
An exact solution of one-dimensional lattice gauge theory at finite temperature and non-zero chemical potential is reviewed for the gauge groups G = Z(N), U(N), SU(N) for all values of N and the number of fermion flavors N f .
O. Borisenko, V. Chelnokov, S. Voloshyn, P. Yefanov   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Understanding Streaming Instabilities in the Limit of High Cosmic-Ray Current Density

The Astrophysical Journal
A critical component of particle acceleration in astrophysical shocks is the nonresonant (Bell) instability, where the streaming of cosmic rays (CRs) leads to the amplification of magnetic fields necessary to scatter particles.
Emily Lichko, Damiano Caprioli, Benedikt Schroer, Siddhartha Gupta   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source